The effects of aging on longterm potentiation (LTP) in the dentate gyrus (DG) and CA1 are
well documented, but LTP at the medial perforant path (MPP)CA3 synapse of aged animals …

Old, memory-deficient rats do not show a change in the threshold for long-term potentiation
(LTP) induction in hippocampal region CA1. This observation suggests that defective NMDA …

Synaptic plasticity in the mammalian central nervous system has been the subject of intense
investigation for the past four decades. Long-term potentiation (LTP), a major reflection of …

Age-dependent alterations in the induction of long-term potentiation (LTP) are well
documented, providing a likely neural basis for memory decline associated with aging …

Altered hippocampal synaptic plasticity may underlie age-related memory impairment. In
acute hippocampal slices from aged (22–24 mo) and young adult (1–12 mo) male Brown …

Aging is associated with an impaired ability to maintain longterm potentiation (LTP), but the
underlying cause of the impairment remains unclear. To gain a better understanding of the …

F344 rats of various ages (2–3 months, 15–16 months, and 24–25 months) were tested on a
spatial memory task. The 15-and 24-month-old rat groups showed impaired acquisition and …

Shankar, Subbakrishna, Timothy J. Teyler, and Norman Robbins. Aging differentially alters
forms of long-term potentiation in rat hippocampal area CA1. J. Neurophysiol. 79: 334–341 …

The hippocampus is essential for the formation of certain types of memory, and synaptic
plasticity such as longterm potentiation (LTP) is widely accepted as a cellular basis of …

Homosynaptic long-term depression (LTD) and reversal of long-term potentiation (LTP) were
examined extracellularly at CA3–CA1 synapses in stratum radiatum of slices from adult (6–9 …