The metalloproteinase family includes MMP, ADAM and ADAMTS proteases. Mice deficient
in individual or pairs of metalloproteinases have been generated, and a number of these …

Matrix metalloproteinases (MMPs) are degrading enzymes that have a pivotal function in
extracellular matrix remodeling. More than half of the MMP members are expressed by bone …

Matrix metalloproteinases (MMPs) degrade most components of the extracellular matrix
(ECM), as well as many nonECM molecules. MMPs participate in (1) degradation of ECM to …

Matrix metalloproteinases (MMPs) are members of a family of zinc-dependent proteolytic
enzymes. Several of the MMPs are expressed at high levels in bone and cartilage in …

Bone is a dynamic organ that undergoes constant remodeling, an energetically costly
process by which old bone is replaced and localized bone defects are repaired to renew the …

The matrix metalloproteinases (MMPs) are one of the major families of proteinases that play
key roles in the responses of cells to their microenvironment. Most notably the MMPs have …

Extracellular matrix production and degradation by bone cells are critical steps in bone
metabolism. Mutations of the gene encoding MMP-2, an extracellular matrix-degrading …

Genetic diseases and knockout mice stress the importance of matrix metalloproteinases
(MMPs) in skeletal turnover. Our study aims at clarifying which MMPs are expressed by …

During osteogenesis, in vitro, of tibialderived rat osteoblasts (ROB) and derived clones,
changes occur in the interactions of mature osteoblasts with the endogenous extracellular …

[Frontiers in Bioscience 11, 1702-1715, May 1, 2006] 1702 Matrix metalloproteinases: role in
skeletal development and growth pla Page 1 [Frontiers in Bioscience 11, 1702-1715, May 1 …