The classic motor symptoms of Parkinson's disease result from the progressive death of
dopaminergic neurons within the substantia nigra. To date the relatively selective …

The massive, early and relatively circumscribed death of the dopaminergic neurons of the
substantia nigra in Parkinson's disease has not yet been adequately explained. The …

A characteristic feature of both Parkinson's disease (idiopathic paralysis agitans) and normal
aging is loss of pigmented neurons in the substantia nigra. This has been found to correlate …

Neuromelanin (NM) is a granular, dark brown pigment produced in some but not all of the
dopaminergic neurons of the human substantia nigra (SN). In Parkinson's disease (PD) the …

This article briefly reviews findings from studies on neuromelanin (NM)-bound ferric iron,
which provide unique insights into the physiological functions of NM and possible …

Neuromelanin (NM) is a peculiar biochemical component of several neurons in the
Substantia Nigra (SN), the target area of the degenerative process in Parkinson Disease …

Parkinson's disease is a common neurodegenerative disorder with a mainly sporadic
aetiology, although a number of monogenic familiar forms are known. Most of the motor …

Neuromelanin (NM) is a dark-coloured pigment produced in the dopaminergic neurons of
the human substantia nigra (SN). The function of NM within the pigmented neurons is …

The mechanisms that lead to degeneration of melanized dopaminergic neurons in the brain
stem, and particularly in the substantia nigra (SN) in patients with Parkinson's disease (PD) …

Recent studies in Parkinson's disease suggest that the degeneration of the nigrostriatal
melanincontaining dopaminergic neurons results from toxic effects of free radicals, which …