Publisher Summary The cholinergic system of the brain has been implicated in memory
function. Evidence for this role is anatomical, physiological and pharmacological. In all …

The cholinergic receptors are classically divided into two kinds, namely the nicotinic
acetylcholine receptor and the muscarinic acetyl-choline receptor. The existence of these …

A general review of cholinergic receptors in human brain is presented. The paper focuses
upon changes in normal aging brain and in Alzheimer disease. Studies from five different …

Cholinergic receptors (muscarinic subtypes M1 and M2, and putative nicotinic binding) have
been examined in the hippocampus obtained at autopsy from a variety of patients with …

Publisher Summary This chapter describes the cholinergic system in Alzheimer disease
(AD). Choline acetyltransferase (ChAT), the synthetic enzyme for acetylcholine (ACh), is …

Publisher Summary This chapter reviews the status of the human and animal pharmacology
of the cholinergic system, particularly regarding the use of cholinergic agonists as …

The past decade has witnessed an enormous increase in our knowledge of the variety and
complexity of neuropathological and neurochemical changes in Alzheimer's disease …

Abstract Whitehouse, Peter J. and Kin Sing Au: Cholinergic receptors in aging and
Alzheimer's disease. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 1986, 10 (3–5): 665 …

The brain systems mostly affected by Alzheimer's disease (AD) are listed in Table 1 (Rossor
et al., 1982; Bird et al., 1983; Davies, 1979). They include either neuronal populations which …

Normal aging in experimental animals and humans has been demonstrated to affect various
aspects of central cholinergic functions. Although deficits at the levels of the number of …