[HTML][HTML] Regulation mechanism of ferroptosis and its research progress in tumor immunotherapy

J Xu, X Lin, T Han, Q Zhou, Y Su, S Jiang… - Frontiers in Molecular …, 2022 - frontiersin.org
Ferroptosis is a novel regulatory cell death, which is characterized by iron dependency and
mainly caused by accumulation of intracellular lipid peroxides and reactive oxygen species …

[HTML][HTML] Opportunities for ferroptosis in cancer therapy

KM Fujihara, BZ Zhang, NJ Clemons - Antioxidants, 2021 - mdpi.com
A critical hallmark of cancer cells is their ability to evade programmed apoptotic cell death.
Consequently, resistance to anti-cancer therapeutics is a hurdle often observed in the clinic …

Role of oxidative stressinduced ferroptosis in cancer therapy

K Li, C Fan, J Chen, X Xu, C Lu… - Journal of Cellular and …, 2024 - Wiley Online Library
Ferroptosis is a distinct mode of cell death, distinguishing itself from typical apoptosis by its
reliance on the accumulation of iron ions and lipid peroxides. Cells manifest an imbalance …

Ferroptosis: mechanisms, biology and role in disease

X Jiang, BR Stockwell, M Conrad - Nature reviews Molecular cell …, 2021 - nature.com
The research field of ferroptosis has seen exponential growth over the past few years, since
the term was coined in 2012. This unique modality of cell death, driven by iron-dependent …

[HTML][HTML] Ferroptosis in cancer cell biology

CM Bebber, F Müller, L Prieto Clemente, J Weber… - Cancers, 2020 - mdpi.com
A major hallmark of cancer is successful evasion of regulated forms of cell death. Ferroptosis
is a recently discovered type of regulated necrosis which, unlike apoptosis or necroptosis, is …

Role of ferroptosis in gastrointestinal tumors: From mechanisms to therapies

C Si, X Zhou, J Deng, S Ye, L Kong… - Cell Biology …, 2022 - Wiley Online Library
Ferroptosis is an irondependent nonapoptotic regulated cell death, which is mainly caused
by an abnormal increase in lipid oxygen free radicals and an imbalance in redox …

[HTML][HTML] Ferroptosis as new therapeutic targets in cancer: From molecular mechanisms to therapeutic opportunities

J Chen, X Chen - Frontiers in Pharmacology, 2022 - frontiersin.org
Ferroptosis is a new form of programmed cell death characterized by iron-dependent
accumulation of lipid reactive oxygen species (ROS). In the process of ferroptosis, excessive …

[HTML][HTML] Ferroptosis in cancer progression

R Zhang, J Chen, S Wang, W Zhang, Q Zheng, R Cai - Cells, 2023 - mdpi.com
Ferroptosis is a newly discovered iron-dependent form of regulated cell death driven by
phospholipid peroxidation and associated with processes including iron overload, lipid …

[HTML][HTML] Emerging mechanisms and targeted therapy of ferroptosis in cancer

H Wang, Y Cheng, C Mao, S Liu, D Xiao, J Huang… - Molecular Therapy, 2021 - cell.com
Ferroptosis is an iron-and lipid reactive oxygen species (ROS)-dependent form of
programmed cell death that is distinct from other forms of regulatory cell death at the …

Targeting ferroptosis as a vulnerability in cancer

G Lei, L Zhuang, B Gan - Nature Reviews Cancer, 2022 - nature.com
Ferroptosis is an iron-dependent form of regulated cell death that is triggered by the toxic
build-up of lipid peroxides on cellular membranes. In recent years, ferroptosis has garnered …