Bacterial β-glucuronidases play key roles in the deconjugation of a variety of endogenous
and drug glucuronides, thus have been recognized as important targets to modulate the …

Intestinal bacterial β-glucuronidases, the key enzymes responsible for the hydrolysis of
various glucuronides into free aglycone, have been recognized as key targets for treating …

Abstract β-Glucuronidase plays a vital role in the metabolism of drugs and endogenous
substance. Herein, we assayed the inhibitory effects of thirty-six flavonoids (1–36) toward β …

Gut microbial β-glucuronidases (GUSs) inhibition is a new approach for managing some
diseases and medication therapy. However, the structural and functional complexity of GUSs …

Gut bacterial β-glucuronidase (GUS) plays a pivotal role in the metabolism and reactivation
of a vast of glucuronide conjugates of both endogenous and xenobiotic compounds in the …

Gut microbial β-glucuronidases show varied substrate specificity and inhibition propensity,
highlighting the necessity of discovering broad-spectrum β-glucuronidase inhibitor to meet …

The beneficial pharmacological effects of flavonoids such as chemoprevention against
cancer, aging, and heart diseases are severely limited due to their extensive in vivo …

Flavonoids are widely distributed phytochemicals in vegetables, fruits and medicinal plants.
Recent studies demonstrate that some natural flavonoids are potent inhibitors of the human …

As an edible traditional Chinese herb, Fructus psoraleae (FP) has been widely used in Asia
for the treatment of vitiligo, bone fracture and osteoporosis. Several cases on markedly …

β-Glucuronidases of intestinal bacteria are capable of retoxifying compounds that have been
detoxified by liver glucuronidation, which is one of the most important detoxication …