[HTML][HTML] Modulation of the hypothalamic-pituitary-adrenal axis by early life stress exposure

M Van Bodegom, JR Homberg… - Frontiers in cellular …, 2017 - frontiersin.org
Exposure to stress during critical periods in development can have severe long-term
consequences, increasing overall risk on psychopathology. One of the key stress response …

[HTML][HTML] Early-life stress, HPA axis adaptation, and mechanisms contributing to later health outcomes

J Maniam, C Antoniadis, MJ Morris - Frontiers in endocrinology, 2014 - frontiersin.org
Stress activates the hypothalamic–pituitary–adrenal (HPA) axis, which then modulates the
degree of adaptation and response to a later stressor. It is known that early-life stress can …

Early life stress and trauma: developmental neuroendocrine aspects of prolonged stress system dysregulation

A Agorastos, P Pervanidou, GP Chrousos, G Kolaitis - Hormones, 2018 - Springer
Experience of early life stress (ELS) and trauma is highly prevalent in the general population
and has a high public health impact, as it can trigger a health-related risk cascade and lead …

[HTML][HTML] Childhood trauma, the HPA axis and psychiatric illnesses: a targeted literature synthesis

F Murphy, A Nasa, D Cullinane, K Raajakesary… - Frontiers in …, 2022 - frontiersin.org
Studies of early life stress (ELS) demonstrate the long-lasting effects of acute and chronic
stress on developmental trajectories. Such experiences can become biologically …

Factors promoting vulnerability to dysregulated stress reactivity and stressrelated disease

AL Russell, JG Tasker, AB Lucion… - Journal of …, 2018 - Wiley Online Library
Effective coordination of the biological stress response is integral for the behavioural well
being of an organism. Stress reactivity is coordinated by an interplay of the neuroendocrine …

[HTML][HTML] Dysregulated hypothalamic–pituitary–adrenal axis function contributes to altered endocrine and neurobehavioral responses to acute stress

SA Kinlein, CD Wilson, IN Karatsoreos - Frontiers in psychiatry, 2015 - frontiersin.org
Organisms react to environmental challenges by activating a coordinated set of brain–body
responses known as the stress response. These physiological and behavioral …

Environmental stressors and epigenetic control of the hypothalamic-pituitary-adrenal axis

RS Lee, A Sawa - Neuroendocrinology, 2015 - karger.com
In this review, we provide a brief summary of several key studies that broaden our
understanding of stress and its epigenetic control of the function and behavior of the …

HPA axis responses to psychological challenge linking stress and disease: What do we know on sources of intra-and interindividual variability?

S Zänkert, S Bellingrath, S Wüst, BM Kudielka - Psychoneuroendocrinology, 2019 - Elsevier
Stress is an ubiquitous phenomenon with significant impact on human physiology when it
lasts too long, when it is too intense, or when it hits vulnerable individuals. Examining the …

Hypothalamic-pituitary-adrenal axis dysfunction by early life stress

MF Juruena, M Bourne, AH Young, AJ Cleare - Neuroscience letters, 2021 - Elsevier
Evidence indicates that early life stress (ELS) may act as a risk factor for the development
and maintenance of adulthood severe mental health disorders due to persistent …

Stress physiology and developmental psychopathology: past, present, and future

JR Doom, MR Gunnar - Development and psychopathology, 2013 - cambridge.org
Research on the hypothalamic–pituitary–adrenocortical (HPA) axis has emerged as a vital
area within the field of developmental psychopathology in the past 25 years. Extensive …