[HTML][HTML] Modulation of the hypothalamic-pituitary-adrenal axis by early life stress exposure
M Van Bodegom, JR Homberg… - Frontiers in cellular …, 2017 - frontiersin.org
Exposure to stress during critical periods in development can have severe long-term
consequences, increasing overall risk on psychopathology. One of the key stress response …
consequences, increasing overall risk on psychopathology. One of the key stress response …
[HTML][HTML] Early-life stress, HPA axis adaptation, and mechanisms contributing to later health outcomes
Stress activates the hypothalamic–pituitary–adrenal (HPA) axis, which then modulates the
degree of adaptation and response to a later stressor. It is known that early-life stress can …
degree of adaptation and response to a later stressor. It is known that early-life stress can …
Early life stress and trauma: developmental neuroendocrine aspects of prolonged stress system dysregulation
Experience of early life stress (ELS) and trauma is highly prevalent in the general population
and has a high public health impact, as it can trigger a health-related risk cascade and lead …
and has a high public health impact, as it can trigger a health-related risk cascade and lead …
[HTML][HTML] Childhood trauma, the HPA axis and psychiatric illnesses: a targeted literature synthesis
F Murphy, A Nasa, D Cullinane, K Raajakesary… - Frontiers in …, 2022 - frontiersin.org
Studies of early life stress (ELS) demonstrate the long-lasting effects of acute and chronic
stress on developmental trajectories. Such experiences can become biologically …
stress on developmental trajectories. Such experiences can become biologically …
Factors promoting vulnerability to dysregulated stress reactivity and stressrelated disease
Effective coordination of the biological stress response is integral for the behavioural well
being of an organism. Stress reactivity is coordinated by an interplay of the neuroendocrine …
being of an organism. Stress reactivity is coordinated by an interplay of the neuroendocrine …
[HTML][HTML] Dysregulated hypothalamic–pituitary–adrenal axis function contributes to altered endocrine and neurobehavioral responses to acute stress
SA Kinlein, CD Wilson, IN Karatsoreos - Frontiers in psychiatry, 2015 - frontiersin.org
Organisms react to environmental challenges by activating a coordinated set of brain–body
responses known as the stress response. These physiological and behavioral …
responses known as the stress response. These physiological and behavioral …
Environmental stressors and epigenetic control of the hypothalamic-pituitary-adrenal axis
RS Lee, A Sawa - Neuroendocrinology, 2015 - karger.com
In this review, we provide a brief summary of several key studies that broaden our
understanding of stress and its epigenetic control of the function and behavior of the …
understanding of stress and its epigenetic control of the function and behavior of the …
HPA axis responses to psychological challenge linking stress and disease: What do we know on sources of intra-and interindividual variability?
S Zänkert, S Bellingrath, S Wüst, BM Kudielka - Psychoneuroendocrinology, 2019 - Elsevier
Stress is an ubiquitous phenomenon with significant impact on human physiology when it
lasts too long, when it is too intense, or when it hits vulnerable individuals. Examining the …
lasts too long, when it is too intense, or when it hits vulnerable individuals. Examining the …
Hypothalamic-pituitary-adrenal axis dysfunction by early life stress
Evidence indicates that early life stress (ELS) may act as a risk factor for the development
and maintenance of adulthood severe mental health disorders due to persistent …
and maintenance of adulthood severe mental health disorders due to persistent …
Stress physiology and developmental psychopathology: past, present, and future
Research on the hypothalamic–pituitary–adrenocortical (HPA) axis has emerged as a vital
area within the field of developmental psychopathology in the past 25 years. Extensive …
area within the field of developmental psychopathology in the past 25 years. Extensive …