Ligand binding studies show marked reductions of nicotinic, but not of muscarinic binding
sites in Alzheimer's disease. Using monoclonal antibodies we studied …

The cholinergic receptors are classically divided into two kinds, namely the nicotinic
acetylcholine receptor and the muscarinic acetyl-choline receptor. The existence of these …

In Alzheimer's disease (AD), there is a loss of presynaptic cholinergic markers in the
cerebral cortex, but the nature of cholinergic receptor changes is unclear. In this study,[3 …

The total population of muscarinic receptors and a subpopulation of muscarinic receptors
with high affinity for agonists were measured with [3 H] quinuclidinyl benzilate and [3 H] …

A review of studies on nicotinic cholinergic receptors in human brain is presented. The
paper focusses upon changes in normal aging brain and in Alzheimer disease (AD). Studies …

The cellular distribution of muscarinic acetylcholine receptor protein in the frontal cortex of
Alzheimer (AD) patients, age-matched and middle-aged controls was assessed …

The cellular distribution of nicotinic acetylcholine receptors was studied in the frontal cortex
(area 10) of 1) Alzheimer patients and compared to 2) age-matched and 3) middle-aged …

Publisher Summary The cholinergic system of the brain has been implicated in memory
function. Evidence for this role is anatomical, physiological and pharmacological. In all …

Nicotinic cholinergic receptors were measured in human frontal cortex using [3 H] nicotine
and [3 H] acetylcholine (in the presence of atropine) as receptor ligands. A parallel marked …

Several studies suggest that impaired cholinergic function plays an important role in the
memory and cognitive deficits of normal aging. Numerous neurochemical studies performed …