The brain systems mostly affected by Alzheimer's disease (AD) are listed in Table 1 (Rossor
et al., 1982; Bird et al., 1983; Davies, 1979). They include either neuronal populations which …

Neuronal nicotinic acetylcholine receptors labelled with tritiated agonists are reduced in the
cerebral cortex in Alzheimer's disease (AD), but to date it has not been demonstrated which …

Loss of cortical nicotinic acetylcholine receptors with high affinity for agonists (20–50%) in
patients with Alzheimer's disease is a common finding. Recent immunochemical analyses …

We have investigated possible changes in the mRNA levels for several α and β subunits of
the nicotinic acetylcholine receptor (nAChR) and the level of binding for nicotinic ligands in 7 …

Anatomical, physiological, and pharmacological evidence has implicated the cholinergic
systems of the brain in memory function (Becker, 1991). Not surprisingly, these systems are …

The status of cholinergic receptors in dementia is related to the question of potential
cholinergic therapy. Whilst muscarinic receptor binding is generally reported to be normal or …

Recent molecular, immunologic, and physiological studies have revealed that wide variety
of nicotinic acetylcholine receptors exist in the nervous system of vertebrates. Nicotinic …

Postmortem cerebral neocortical and hippocampal samples were taken from patients who
died with dementia of the Alzheimer type (DAT) and individuals without diagnoses of …

Cholinergic nicotinic and muscarinic receptor binding were measured in post mortem
human brain tissue, using low (nM) concentrations of (3 H)-nicotine to detect predominately …