Brain nicotinic receptors were studied in the frontal cortex, temporal cortex, hippocampus
and caudate nucleus in patients with Parkinson's disease (PD), Alzheimer's disease (AD) …

Neuropathological and biochemical examinations of the brains of patients suffering from
senile dementia of the Alzheimer type (SDAT) reveal characterstic abnormalities. These …

Human brain ageing is associated with reductions in a variety of nicotinic receptors
subtypes, whereas changes in age-related disorders including Alzheimer's disease or …

Normal aging and Alzheimer's disease are characterized by similar morphological, chemical
and behavioral changes. These include cell loss, senile plaque formation, the presence of …

Over the last 30 years, it has become well-recognized that drugs blocking the muscarinic
subtype of acetylcholine (ACh) receptors in the brain have selective and reproducible effects …

Previous studies indicate that a 20–30% decline in muscarinic acetylcholine receptor
binding occurs in localized areas of rat brain during aging. In this study, reduced [3H] …

Publisher Summary This chapter describes the cholinergic system in Alzheimer disease
(AD). Choline acetyltransferase (ChAT), the synthetic enzyme for acetylcholine (ACh), is …

Impairment of cholinergic transmission and decreased numbers of nicotinic binding sites are
wellknown features accompanying the cognitive dysfunction seen in Alzheimer's disease …

Muscarinic and nicotinic cholinergic receptor distribution was studied by dry-mount
autoradiography in brains obtained postmortem from patients with senile dementia of …

Receptor binding studies have uniform-ly found a significant reduction in the density of
neuronal nicotinic cholinergic receptors in postmortem tissue obtained from Alzheimer's …