Discovery of a naturally occurring broad-spectrum inhibitor against gut bacterial β-glucuronidases from Ginkgo biloba
Y Bai, L Chen, PP Wang, YQ Tang, DC Wu… - Food & Function, 2021 - pubs.rsc.org
Gut bacterial β-glucuronidases (GUS) play an important role in deconjugation of various O-
glucuronides, which are tightly linked with the drug-induced intestinal toxicity. Increasing …
glucuronides, which are tightly linked with the drug-induced intestinal toxicity. Increasing …
Structure-activity relationships of flavonoids as natural inhibitors against E. coli β-glucuronidase
ZM Weng, P Wang, GB Ge, ZR Dai, DC Wu… - Food and Chemical …, 2017 - Elsevier
Bacterial β-glucuronidases play key roles in the deconjugation of a variety of endogenous
and drug glucuronides, thus have been recognized as important targets to modulate the …
and drug glucuronides, thus have been recognized as important targets to modulate the …
Discovery of a botanical compound as a broad-spectrum inhibitor against gut microbial β-glucuronidases from the Tibetan medicine Rhodiola crenulata
L Chen, XD Hou, GH Zhu, J Huang, ZB Guo… - International Journal of …, 2024 - Elsevier
Gut microbial β-glucuronidases (gmβ-GUS) played crucial roles in regulating a variety of
endogenous substances and xenobiotics on the circulating level, thus had been recognized …
endogenous substances and xenobiotics on the circulating level, thus had been recognized …
Inhibition and structure-activity relationship of dietary flavones against three Loop 1-type human gut microbial β-glucuronidases
Gut microbial β-glucuronidases (GUSs) inhibition is a new approach for managing some
diseases and medication therapy. However, the structural and functional complexity of GUSs …
diseases and medication therapy. However, the structural and functional complexity of GUSs …
Beta-glucuronidase inhibition by constituents of mulberry bark
Y Bai, L Chen, YF Cao, XD Hou, SN Jia, Q Zhou… - Planta …, 2021 - thieme-connect.com
Intestinal bacterial β-glucuronidases, the key enzymes responsible for the hydrolysis of
various glucuronides into free aglycone, have been recognized as key targets for treating …
various glucuronides into free aglycone, have been recognized as key targets for treating …
[HTML][HTML] Identification of Escherichia coli β-glucuronidase inhibitors from Polygonum cuspidatum Siebold & Zucc.
JX Li, Y Wang, Y Hao, XK Huo, CP Sun… - Brazilian Journal of …, 2023 - SciELO Brasil
Gut bacterial β-glucuronidase (GUS) can reactivate xenobiotics that exert enterohepatic
circulation-triggered gastrointestinal tract toxicity. GUS inhibitors can alleviate drug-induced …
circulation-triggered gastrointestinal tract toxicity. GUS inhibitors can alleviate drug-induced …
Prenylflavonoids sanggenon C and kuwanon G from mulberry (Morus alba L.) as potent broad-spectrum bacterial β-glucuronidase inhibitors: Biological evaluation …
Gut microbial β-glucuronidases show varied substrate specificity and inhibition propensity,
highlighting the necessity of discovering broad-spectrum β-glucuronidase inhibitor to meet …
highlighting the necessity of discovering broad-spectrum β-glucuronidase inhibitor to meet …
Amentoflavone from Selaginella tamariscina as a potent inhibitor of gut bacterial β-glucuronidase: Inhibition kinetics and molecular dynamics stimulation
XG Tian, JK Yan, CP Sun, JX Li, J Ning, C Wang… - Chemico-Biological …, 2021 - Elsevier
Gut bacterial β-glucuronidase (GUS) plays a pivotal role in the metabolism and reactivation
of a vast of glucuronide conjugates of both endogenous and xenobiotic compounds in the …
of a vast of glucuronide conjugates of both endogenous and xenobiotic compounds in the …
Discovery of a series of 5-phenyl-2-furan derivatives containing 1, 3-thiazole moiety as potent Escherichia coli β-glucuronidase inhibitors
TS Zhou, LL He, J He, ZK Yang, ZY Zhou, AQ Du… - Bioorganic …, 2021 - Elsevier
Gut microbial β-glucuronidases have drawn much attention due to their role as a potential
therapeutic target to alleviate some drugs or their metabolites-induced gastrointestinal …
therapeutic target to alleviate some drugs or their metabolites-induced gastrointestinal …
[HTML][HTML] Inhibition of gut bacterial β-glucuronidase by chemical components from black tea: Inhibition interactions and molecular mechanism
CP Sun, XG Tian, L Feng, C Wang, JX Li… - Arabian Journal of …, 2021 - Elsevier
Gut bacterial β-glucuronidase is regarded as an important molecular target for several
therapeutic applications. Inhibitors of β-glucuronidase can effectively alleviate the drug …
therapeutic applications. Inhibitors of β-glucuronidase can effectively alleviate the drug …
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