KIF2C: a novel link between Wnt/β-catenin and mTORC1 signaling in the pathogenesis of hepatocellular carcinoma

S Wei, M Dai, C Zhang, K Teng, F Wang, H Li… - Protein & …, 2021 - academic.oup.com
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and is the
fourth-leading cause of cancer-related deaths worldwide. HCC is refractory to many …

Upregulation of kinesin family member 4A enhanced cell proliferation via activation of Akt signaling and predicted a poor prognosis in hepatocellular carcinoma

Y Huang, H Wang, Y Lian, X Wu, L Zhou, J Wang… - Cell death & …, 2018 - nature.com
Hepatocellular carcinoma (HCC) is the third most frequent cause of cancer-related death
worldwide, and the molecular pathogenesis and development of HCC are largely unknown …

KIF11 promotes proliferation of hepatocellular carcinoma among patients with liver cancers

ZD Hu, Y Jiang, HM Sun, J Wang… - BioMed research …, 2021 - Wiley Online Library
Background. Hepatocellular carcinoma (HCC) lacks effective treatments and has a poor
prognosis. Therefore it is needed to develop more effective drug targets. Kinesin family …

Upregulate KIF4A enhances proliferation, invasion of hepatocellular carcinoma and indicates poor prognosis across human cancer types

G Hou, C Dong, Z Dong, G Liu, H Xu, L Chen, L Liu… - Scientific reports, 2017 - nature.com
Hepatocellular carcinoma (HCC) is one of the most aggressive and heterogeneous cancers
worldwide. Herein, we demonstrate KIF4A (Chromosome-associated kinesin KIF4A) as a …

Kinesin superfamily protein expression and its association with progression and prognosis in hepatocellular carcinoma

J Chen, S Li, S Zhou, S Cao, Y Lou… - Journal of Cancer …, 2017 - journals.lww.com
Objectives: In this study, we characterized the expression of 32 other kinesin superfamily
proteins (KIFs) and analyzed their association with the progression and prognosis of …

[HTML][HTML] Kinesin family members KIF2C/4A/10/11/14/18B/20A/23 predict poor prognosis and promote cell proliferation in hepatocellular carcinoma

X Li, W Huang, W Huang, T Wei, W Zhu… - American Journal of …, 2020 - ncbi.nlm.nih.gov
Kinesin superfamily proteins (KIFs) comprise a family of molecular motors that transport
membranous organelles and protein complexes in a microtubule-and ATP-dependent …

[HTML][HTML] Kinesin family member 15 promotes cancer stem cell phenotype and malignancy via reactive oxygen species imbalance in hepatocellular carcinoma

Q Li, J Qiu, H Yang, G Sun, Y Hu, D Zhu, Z Deng… - Cancer letters, 2020 - Elsevier
The development and progression of hepatocellular carcinoma (HCC) is associated with the
presence of cancer stem cells (CSCs). In the present study, kinesin family member 15 …

KIFC1 is activated by TCF-4 and promotes hepatocellular carcinoma pathogenesis by regulating HMGA1 transcriptional activity

K Teng, S Wei, C Zhang, J Chen, J Chen… - Journal of Experimental …, 2019 - Springer
Background Kinesins play important roles in the development and progression of many
human cancers. The functions and underlying mechanisms of kinesin family member C1 …

The role of kinesin KIF18A in the invasion and metastasis of hepatocellular carcinoma

W Luo, M Liao, Y Liao, X Chen, C Huang, J Fan… - World journal of surgical …, 2018 - Springer
Background KIF18A is associated with a variety of tumours; however, the specific
mechanism of action of KIF18A in hepatocellular carcinoma (HCC) remains unclear. In this …

[HTML][HTML] KIF20A promotes cellular malignant behavior and enhances resistance to chemotherapy in colorectal cancer through regulation of the JAK/STAT3 signaling …

M Xiong, K Zhuang, Y Luo, Q Lai, X Luo, Y Fang… - Aging (albany …, 2019 - ncbi.nlm.nih.gov
Background/Aims: Kinesin family member 20A (KIF20A) is upregulated in multiple cancers
and plays important roles in promoting malignant behavior, whereas its exact role in CRC …