Regulatory T-cells (Tregs) can facilitate immune evasion by tumor cells by dampening anti-
tumor immunity. Reduced Teff/Treg ratio and enhanced Treg functional activity have been …

T Regulatory cells (Tregs) act as a double-edged sword by regulating immune homeostasis
(protective role) and inhibiting immune responses in different disease settings (pathological …

Although cancers arise from genetic mutations enabling cells to proliferate uncontrollably,
they cannot thrive without failure of the anticancer immunity due in a large part to the tumor …

Advances in our understanding οf tumor immunity have prompted a paradigm shift in
oncology, with the emergence of immunotherapy, where therapeutic agents are used to …

Inhibitory checkpoint blockade has significantly improved patient response rate across
numerous tumor types. However, most patients remain unresponsive to immunotherapy …

Regulatory T cells (Tregs) play essential roles in immune homeostasis; however, their role in
tumor microenvironment (TME) is not completely evident. Several studies reported that …

With the broad application of cancer immunotherapies such as immune checkpoint inhibitors
in multiple cancer types, the immunological landscape in the tumor microenvironment (TME) …

Cancer immunotherapy involving blockade of immune checkpoint molecules, such as CTLA
4 and PD1, has shown remarkable clinical success across several types of malignancies …

The treatment of many cancers has been revolutionized by immune checkpoint blockade
(ICB) as a standard-of-care therapeutic. Despite many successes, a large proportion of …

Immune checkpoint inhibitors (ICI), which target immune regulatory pathways to unleash
antitumor responses, have revolutionized cancer immunotherapy. Despite the remarkable …