ABSTRACT B-type cyclins in association with Cdk1 mediate key steps of mitosis and
meiosis, by phosphorylating a plethora of substrates. Progression through the meiotic cell …

CDK1-cyclin B1 is a universal cell cycle kinase required for mitotic/meiotic cell cycle entry
and its activity needs to decline for mitotic/meiotic exit. During their maturation, mouse …

Meiosis poses unique challenges because two rounds of chromosome segregation must be
executed without intervening DNA replication. Mammalian cells express numerous …

Successful mitosis requires that cyclin B1: CDK1 kinase activity remains high until
chromosomes are correctly aligned on the mitotic spindle. It has therefore been unclear why …

All eukaryotic cells, including oocytes, utilize an engine called cyclin-dependent kinase
(Cdk) to drive the cell cycle. Cdks are activated by a co-factor called cyclin, which regulates …

Cdk1-cyclin B1 kinase activity drives oocytes through meiotic maturation. It is regulated by
the phosphorylation status of cdk1 and by its spatial organisation. Here we used a cyclin B1 …

Cyclins, as regulatory partners of cyclin-dependent kinases (CDKs), control the switch-like
cell cycle transitions that orchestrate orderly duplication and segregation of genomes …

Here we have used siRNAs and time-lapse epifluorescence microscopy to examine the
roles of various candidate mitotic cyclins in chromatin condensation in HeLa cells. Knocking …

Mammalian oocytes are arrested at the prophase of the first meiotic division for months and
even years, depending on species. Meiotic resumption of fully grown oocytes requires …

Cyclins associate with cyclin-dependent serine/threonine kinase 1 (CDK1) to generate the M
phase-promoting factor (MPF) activity essential for progression through mitosis and meiosis …