Abnormal early brain development in autism

E Courchesne - Molecular psychiatry, 2002 - nature.com
A pivotal period in human brain and behavioral development occurs in the first years of life.
These years are normally characterized by a degree and variety of neuroanatomical change …

Autism at the beginning: microstructural and growth abnormalities underlying the cognitive and behavioral phenotype of autism

E Courchesne, E Redcay, JT Morgan… - Development and …, 2005 - cambridge.org
Autistic symptoms begin in the first years of life, and recent magnetic resonance imaging
studies have discovered brain growth abnormalities that precede and overlap with the onset …

The neurobiological basis of autism from a developmental perspective

N Akshoomoff, K Pierce, E Courchesne - Development and …, 2002 - cambridge.org
Autism is a neurobiological disorder that is diagnosed through careful behavioral
assessment in early childhood. In this paper, we review recent studies that have attempted …

[HTML][HTML] Toward a conceptual framework for early brain and behavior development in autism

J Piven, JT Elison, MJ Zylka - Molecular psychiatry, 2017 - nature.com
Studies of infant siblings of older autistic probands, who are at elevated risk for autism, have
demonstrated that the defining features of autism are not present in the first year of life but …

Structural and functional magnetic resonance imaging of autism

H Cody, K Pelphrey, J Piven - International Journal of Developmental …, 2002 - Elsevier
Magnetic resonance imaging (MRI) of brain structures and function is uniquely suited to
characterize the range of neuroanatomical and physiological changes that characterize the …

Genetic basis of autism: is there a way forward?

V Eapen - Current opinion in psychiatry, 2011 - journals.lww.com
Understanding the neurobiological processes by which genotypes become phenotypes,
along with the advances in developmental neuroscience and neuronal networks at the …

The neuropathology of autism

GJ Blatt - Scientifica, 2012 - Wiley Online Library
Autism is a behaviorally defined neurodevelopmental disorder that affects over 1% of new
births in the United States and about 2% of boys. The etiologies are unknown and they are …

Imaging data in autism: from structure to malfunction

MT Acosta, PL Pearl - Seminars in Pediatric Neurology, 2004 - Elsevier
During the last two decades, neuroimaging studies have improved our knowledge of brain
development and contributed to our understanding of disorders involving the developing …

[HTML][HTML] Genetics studies indicate that neural induction and early neuronal maturation are disturbed in autism

EL Casanova, MF Casanova - Frontiers in cellular neuroscience, 2014 - frontiersin.org
Postmortem neuropathological studies of autism consistently reveal distinctive types of
malformations, including cortical dysplasias, heterotopias, and various …

[HTML][HTML] Mapping early brain development in autism

E Courchesne, K Pierce, CM Schumann, E Redcay… - Neuron, 2007 - cell.com
Although the neurobiology of autism has been studied for more than two decades, the
majority of these studies have examined brain structure 10, 20, or more years after the onset …