The process of cancer cell invasion involves degradation of the extracellular matrix (ECM)
by proteases, integrin adhesion and cell motility. The role of ECM degrading proteases on …

The relative expression of matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs
(TIMPs) is an important determinant in trophoblast invasion of the uterus and tumor invasion …

Behavior of cancer cells is profoundly affected by their microenvironment, which is often
controlled by pericellular proteolysis or the processing of protein components, including …

Activation of the zymogen of matrix metalloproteinase 2 (proMMP-2, progelatinase A)
possibly is one of the key steps in invasion and metastasis of various human carcinomas …

Background/Aims: Tropomyosin-2 (TPM2) plays important roles in functions of the
cytoskeleton, such as cytokinesis, vesicle transport, cell proliferation, migration and …

Abstract MT1-MMP (membrane type-1 matrix metalloproteinase), otherwise known as
MMP14 is a proteolytic enzyme known to be involved in degradating extracellular matrix and …

Abstract Background Membrane Type-1 Matrix Metalloproteinase (MT1-MMP) is a
multifunctional protease implicated in metastatic progression ostensibly due to its ability to …

Membrane-type 1 matrix metalloproteinase (MT1-MMP) is an integral membrane proteinase
that is frequently expressed in malignant cancer cells and has potent invasion-promoting …

Abstract Collagenase-2 (matrix metalloproteinase-8, MMP-8) is an MMP mainly produced by
neutrophils and associated with many inflammatory conditions. We have previously …

Tumor hypoxia has been reported to be a negative prognostic factor in a number of tumor
sites. Both clinical and experimental studies have suggested a positive correlation between …