Diabetes, a complex multisystem metabolic disorder characterized by hyperglycemia, leads
to complications that reduce quality of life and increase mortality. Diabetes pathophysiology …

We present multiple findings on derangements in lipid metabolism in type 2 diabetes. The
increase in the intracellular deposition of triglycerides (TG) in muscles, liver and pancreas in …

Background The diminished glucose lowering effect of insulin in obesity, called “insulin
resistance,” is associated with glucose intolerance, type 2 diabetes, and other serious …

Adipose tissue, when carried around in excessive amounts, predisposes to a large number
of diseases. Epidemiological data show that the prevalence of obesity has significantly …

The relative contributions of insulin resistance and beta-cell dysfunction to the
pathophysiology of Type 2 diabetes have been debated extensively. The concept that a …

Adipose tissue is a complex endocrine organ with an intricate role in whole body
homeostasis. Beyond storing energy, adipose tissue is fundamental in numerous processes …

A discussion of the pathogenesis of type 2 diabetes mellitus must start with a review of
mechanisms involved in the maintenance of normal glucose homeostasis in the basal or …

Adipose tissue metabolism exerts a profound impact on whole-body metabolism. We review
how fuel partitioning between adipocytes and other tissues affects insulin signaling …

Diabetes mellitus is a term that covers a multitude of problems with many etiologies, unified
by one common feature: the pathological elevation of blood glucose. Sustained …

Adipose tissue dysfunction rather than excess adipose tissue mass (defined as obesity) is
mechanistically related to development of metabolic diseases traditionally linked to obesity …