The CACNA1C risk allele selectively impacts on executive function in bipolar type I disorder
MG SoeirodeSouza, DS Bio, VV Dias… - Acta psychiatrica …, 2013 - Wiley Online Library
Objective Calcium channels are important for converting electrical activity into biochemical
events. A single nucleotide polymorphism (SNP)(rs1006737) in the CACNA 1C gene has …
events. A single nucleotide polymorphism (SNP)(rs1006737) in the CACNA 1C gene has …
[HTML][HTML] Evaluation of voltage-dependent calcium channel γ gene families identified several novel potential susceptible genes to schizophrenia
Voltage-gated L-type calcium channels (VLCC) are distributed widely throughout the brain.
Among the genes involved in schizophrenia (SCZ), genes encoding VLCC subunits have …
Among the genes involved in schizophrenia (SCZ), genes encoding VLCC subunits have …
[HTML][HTML] Alteration in basal and depolarization induced transcriptional network in iPSC derived neurons from Timothy syndrome
Background Common genetic variation and rare mutations in genes encoding calcium
channel subunits have pleiotropic effects on risk for multiple neuropsychiatric disorders …
channel subunits have pleiotropic effects on risk for multiple neuropsychiatric disorders …
The impact of the CACNA1C gene polymorphism on frontolimbic function in bipolar disorder
Genome-wide association studies in bipolar disorder (BD) 1 have implicated a single-
nucleotide polymorphism (rs1006737, GA) in the CACNA1C gene, which encodes for the …
nucleotide polymorphism (rs1006737, GA) in the CACNA1C gene, which encodes for the …
Effects of a CACNA1C genotype on attention networks in healthy individuals
M Thimm, T Kircher, T Kellermann, V Markov… - Psychological …, 2011 - cambridge.org
BackgroundRecent genetic studies found the A allele of the variant rs1006737 in the alpha
1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene to be over …
1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene to be over …
Key roles of CACNA1C/Cav1. 2 and CALB1/calbindin in prefrontal neurons altered in cognitive disorders
Importance The risk of mental disorders is consistently associated with variants inCACNA1C
(L-type calcium channel Cav1. 2) but it is not known why these channels are critical to …
(L-type calcium channel Cav1. 2) but it is not known why these channels are critical to …
Reversing frontal disinhibition rescues behavioural deficits in models of CACNA1A-associated neurodevelopment disorders
A Lupien-Meilleur, X Jiang, M Lachance… - Molecular …, 2021 - nature.com
CACNA1A deletions cause epilepsy, ataxia, and a range of neurocognitive deficits,
including inattention, impulsivity, intellectual deficiency and autism. To investigate the …
including inattention, impulsivity, intellectual deficiency and autism. To investigate the …
Genetic analysis of SNPs in CACNA1C and ANK3 gene with schizophrenia: A comprehensive metaanalysis
F Nie, X Wang, P Zhao, H Yang, W Zhu… - American Journal of …, 2015 - Wiley Online Library
Recently, genomewide association studies (GWAS), metaanalyses, and replication
studies focusing on bipolar disorder (BD) have implicated the α1C subunit of the Ltype …
studies focusing on bipolar disorder (BD) have implicated the α1C subunit of the Ltype …
A comprehensive analysis of cell type–specific nuclear RNA from neurons and glia of the brain
AS Reddy, D O'Brien, N Pisat, CT Weichselbaum… - Biological …, 2017 - Elsevier
Background Studies in psychiatric genetics have identified> 100 loci associated with
disease risk, yet many of these loci are distant from protein coding genes. Recent …
disease risk, yet many of these loci are distant from protein coding genes. Recent …
The association of genetic variation in CACNA1C with structure and function of a frontotemporal system
Wang F, McIntosh AM, He Y, Gelernter J, Blumberg HP. The association of genetic variation
in CACNA1C with structure and function of a frontotemporal system. Bipolar Disord 2011 …
in CACNA1C with structure and function of a frontotemporal system. Bipolar Disord 2011 …