Wang F, McIntosh AM, He Y, Gelernter J, Blumberg HP. The association of genetic variation
in CACNA1C with structure and function of a frontotemporal system. Bipolar Disord 2011 …

Background Studies in psychiatric genetics have identified> 100 loci associated with
disease risk, yet many of these loci are distant from protein coding genes. Recent …

The human brain is one of the last frontiers of biomedical research. Genome-wide
association studies (GWAS) have succeeded in identifying thousands of haplotype blocks …

CACNA1I is a candidate schizophrenia risk gene. It encodes the pore-forming human CaV3.
3 α1 subunit, a subtype of voltage-gated calcium channel that contributes to T-type currents …

Abstract Brain Cav1. 2 and Cav1. 3 Ltype Ca2+ channels play key physiological roles in
various neuronal processes that contribute to brain function. Genetic studies have recently …

Chronic stress is known to precipitate and exacerbate neuropsychiatric symptoms, and
exposure to stress is particularly pathological in individuals with certain genetic …

With> 100 common variants associated with schizophrenia risk, establishing their biological
significance is a priority. We sought to establish cognitive effects of risk variants at loci …

CACNA1A loss-of-function mutations classically present as episodic ataxia type 2 (EA2),
with brief episodes of ataxia and nystagmus, or with progressive spinocerebellar ataxia …

Schizophrenia is a complex genetic disorder, the non-Mendelian features of which are likely
complicated by epigenetic factors yet to be elucidated. Here, we performed RNA sequencing …

Purpose Previously, mutations in the voltage-gated calcium channel subunit alpha1 A
(CACNA1A) gene have been reported to be associated with paroxysmal disorders, typically …