Dissemination of carcinoma cells requires the pericellular degradation of the extracellular
matrix, which is mediated by membrane type 1-matrix metalloproteinase (MT1-MMP). In this …

During their metastatic spread, cancer cells need to remodel the extracellular matrix in order
to migrate through stromal compartments adjacent to the primary tumor. Dissemination of …

Invasion of cancer cells into collagen-rich extracellular matrix requires membrane-tethered
membrane type 1–matrix metalloproteinase (MT1-MMP) as the key protease for collagen …

Membrane type 1-matrix metalloproteinase (MT1-MMP), a membrane-tethered protease, is
key for matrix breakdown during cancer invasion and metastasis. Assembly of branched …

Invasive tumor cells use proteases to degrade and migrate through the stromal environment
consisting of a 3D network of extracellular matrix macromolecules. In particular, MT1-MMP, a …

Metastatic tumor cells that actively migrate and invade surrounding tissues rely on
invadopodia to degrade extracellular matrix (ECM) barriers. Invadopodia are membrane …

Invadopodia are ventral membrane protrusions through which invasive cancer cells degrade
the extracellular matrix. They are thought to function in the migration of cancer cells through …

Invadopodia are branched actin-rich structures associated with extracellular matrix (ECM)
degradation that collectively form the invasive machinery of aggressive cancer cells …

Remodeling of the extracellular matrix by carcinoma cells during metastatic dissemination
requires formation of actin-based protrusions of the plasma membrane called invadopodia …

The process by which tumor cells mechanically invade through surrounding stroma into
peripheral tissues is an essential component of metastatic dissemination. The directed …