Isolation, purification, and characterization of immunosuppressive compounds from tripterygium: triptolide and tripdiolide

WZ Gu, R Chen, S Brandwein, J McAlpine… - International journal of …, 1995 - Elsevier
Crude extracts derived from the root of Tripterygium wilfordii Hook f (TWHf) have previously
been demonstrated to have immunosuppressive properties and have been used as anti …

Immunosuppressive and Anti-Inflammatory Mechanisms of Triptolide, the Principal Active Diterpenoid from the Chinese Medicinal Herb Tripterygium wilfordii Hook. f.

D Qiu, PN Kao - Drugs in R & D, 2003 - Springer
Extracts of Tripterygium wilfordii hook. f.(leigong teng, Thundergod vine) are effective in
traditional Chinese medicine for treatment of immune inflammatory diseases including …

[HTML][HTML] Immunosuppressant discovery from Tripterygium wilfordii Hook f: the novel triptolide analog (5R)-5-hydroxytriptolide (LLDT-8)

W Tang, J Zuo - Acta Pharmacologica Sinica, 2012 - nature.com
Abstract The Chinese traditional herb Tripterygium wilfordii Hook f (TwHF) has been widely
used in the treatment of autoimmune and inflammatory diseases. Over the past few decades …

Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium wilfordii Hook F

BJ Chen - Leukemia & lymphoma, 2001 - Taylor & Francis
Triptolide is a diterpenoid triepoxide purified from a Chines herb Tripterygium Wilfordii Hook
F (TWHF). TWHF has been used in traditional Chinese medicine for more than two thousand …

Immunosuppressive terpenoids from extracts of Tripterygium wilfordii

H Duan, Y Takaishi, H Momota, Y Ohmoto, T Taki… - Tetrahedron, 2001 - Elsevier
The clinically used extract (TΠ) of Tripterygium wilfordii Hook f. give 19 new compounds,
including five kaurane diterpenes (1–5), one manoyl oxide diterpene (6), and one abietane …

[HTML][HTML] Immunosuppressive, anti-inflammatory and anti-cancer properties of triptolide: A mini review

S Ziaei, R Halaby - Avicenna journal of phytomedicine, 2016 - ncbi.nlm.nih.gov
Objective: Triptolide, the active component of Tripterygium wilfordii Hook F has been used to
treat autoimmune and inflammatory conditions for over two hundred years in traditional …

The identity of immunosuppressive components of the ethyl acetate extract and chloroform methanol extract (T2) of Tripterygium wilfordii Hook. F.

X Tao, JJ Cai, PE Lipsky - Journal of Pharmacology and Experimental …, 1995 - ASPET
A variety of preparations of Tripterygium wilfordii Hook. F (TWHF) have been reported to be
effective in the treatment of autoimmune diseases, including a chloroform methanol extract …

IMMUNOCHEMICAL CHARACTERIZATION OF THE FUNCTIONAL CONSTITUENTS OF TRIPTERYGIUM WILFORDII CONTRIBUTING TO ITS ANTI …

KF Wong, JK Chan, KL Chan, P Tam… - Clinical and …, 2008 - Wiley Online Library
SUMMARY 1 Tripterygium wilfordii (TW) contains bioactive compounds that possess
immunosuppressive properties. These compounds are considered to be potential drugs in …

Anti-inflammatory and immunosuppressive compounds from Tripterygium wilfordii

J Ma, M Dey, H Yang, A Poulev, R Pouleva, R Dorn… - Phytochemistry, 2007 - Elsevier
The extract of Tripterygium wilfordii Hook F.(TwHF), which showed anti-inflammatory and
immunosuppressive activities in human clinical trials for rheumatoid arthritis, was subjected …

Triptolide in the treatment of psoriasis and other immunemediated inflammatory diseases

R Han, M RostamiYazdi, S Gerdes… - British journal of …, 2012 - Wiley Online Library
Apart from cancer chronic (auto) immunemediated diseases are a major threat for patients
and a challenge for physicians. These conditions include classic autoimmune diseases like …