MT4-MMP: The GPI-anchored membrane-type matrix metalloprotease with multiple functions in diseases

C Yip, P Foidart, A Noël, NE Sounni - International journal of molecular …, 2019 - mdpi.com
MT4-MMP (or MMP17) belongs to the Membrane-Type Matrix Metalloproteinase (MT-MMP)
family. This family of proteases contributes to extracellular matrix remodeling during several …

MT4-(MMP17) and MT6-MMP (MMP25), A unique set of membrane-anchored matrix metalloproteinases: properties and expression in cancer

A Sohail, Q Sun, H Zhao, MM Bernardo, JA Cho… - Cancer and Metastasis …, 2008 - Springer
The process of cancer progression involves the action of multiple proteolytic systems,
among which the family of matrix metalloproteinases (MMPs) play a pivotal role. The MMPs …

MMP25 (MT6-MMP) is highly expressed in human colon cancer, promotes tumor growth, and exhibits unique biochemical properties

Q Sun, CR Weber, A Sohail, MM Bernardo… - Journal of Biological …, 2007 - ASBMB
MMP25 (MT6-MMP) is one of the two glycosylphosphatidylinositol-anchored matrix
metalloproteinases (MMPs) that have been suggested to play a role in pericellular …

Expression of membrane type-1 matrix metalloproteinase, MT1-MMP in human breast cancer and its impact on invasiveness of breast cancer cells

WG Jiang, G Davies, TA Martin… - International …, 2006 - spandidos-publications.com
Abstract MT1-MMP (membrane type-1 matrix metalloproteinase), otherwise known as
MMP14 is a proteolytic enzyme known to be involved in degradating extracellular matrix and …

Molecular mechanisms driven by MT4-MMP in cancer progression

E Muñoz-Sáez, N Moracho, AIR Learte… - International Journal of …, 2023 - mdpi.com
MT4-MMP (or MMP-17) belongs to the membrane-type matrix metalloproteinases (MT-
MMPs), a distinct subset of the MMP family that is anchored to the cell surface, in this case …

Expression and characterization of membrane-type 4 matrix metalloproteinase (MT4-MMP) and its different forms in melanoma

B Hieronimus, J Pfohl, C Busch, L Graeve - Cellular Physiology and …, 2017 - karger.com
Abstract Background/Aims: Membrane-type matrix metalloproteinases (MT-MMPs) are
expressed on the cell surface and hydrolyze extracellular matrix components and signaling …

Membrane-type 4 matrix metalloproteinase promotes breast cancer growth and metastases

V Chabottaux, NE Sounni, CJ Pennington, WR English… - Cancer Research, 2006 - AACR
Membrane-type matrix metalloproteinases (MT-MMP) constitute a subfamily of six distinct
membrane-associated MMPs. Although the contribution of MT1-MMP during different steps …

Tumor cell MT1-MMP is dispensable for osteosarcoma tumor growth, bone degradation and lung metastasis

SZ Ingvarsen, H Gårdsvoll, S van Putten… - Scientific Reports, 2020 - nature.com
The membrane-anchored matrix metalloprotease MT1-MMP is a potent collagenolytic
enzyme with a well-established role in extracellular matrix turnover and cellular invasion into …

Crystal structure of the catalytic domain of MMP-16/MT3-MMP: characterization of MT-MMP specific features

R Lang, M Braun, NE Sounni, A Noël… - Journal of molecular …, 2004 - Elsevier
Membrane-type matrix metalloproteinases (MT-MMPs) have attracted strong attention,
because four of them can activate a key player in the tumor scenario, proMMP …

Progress on the role and mechanism of MT1-MMP in tumor metastasis.

QG Hao, FG Sun, CH Yan, JW Sun - Yi Chuan= Hereditas, 2022 - europepmc.org
The matrix metallopeptidase family (matrix metallopeptidase, MMPs) is a class of zinc-
dependent endopeptidases that can degrade most extracellular matrices. MT1-MMP …