Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder

CM Nievergelt, AX Maihofer, EG Atkinson, CY Chen… - Nature Genetics, 2024 - nature.com
Post-traumatic stress disorder (PTSD) genetics are characterized by lower discoverability
than most other psychiatric disorders. The contribution to biological understanding from …

Genetic risk mechanisms of posttraumatic stress disorder in the human brain

RA Bharadwaj, AE Jaffe, Q Chen… - Journal of …, 2018 - Wiley Online Library
Posttraumatic stress disorder (PTSD) follows exposure to a traumatic event in susceptible
individuals. Recently, genomewide association studies have identified a number of genetic …

Genetic approaches for the study of PTSD: Advances and challenges

SB Banerjee, FG Morrison, KJ Ressler - Neuroscience letters, 2017 - Elsevier
Post-traumatic stress disorder (PTSD) is a highly debilitating stress and anxiety-related
disorder that occurs in response to specific trauma or abuse. Genetic risk factors may …

Genomic approaches to posttraumatic stress disorder: the psychiatric genomic consortium initiative

CM Nievergelt, AE Ashley-Koch, S Dalvie… - Biological …, 2018 - Elsevier
Posttraumatic stress disorder (PTSD) after exposure to a traumatic event is a highly
prevalent psychiatric disorder. Heritability estimates from twin studies as well as from recent …

Gene expression analysis in three posttraumatic stress disorder cohorts implicates inflammation and innate immunity pathways and uncovers shared genetic risk with …

ME Garrett, XJ Qin, D Mehta, MF Dennis… - Frontiers in …, 2021 - frontiersin.org
Posttraumatic stress disorder (PTSD) is a complex psychiatric disorder that can develop
following exposure to traumatic events. The Psychiatric Genomics Consortium PTSD group …

Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program

MB Stein, DF Levey, Z Cheng, FR Wendt… - Nature …, 2021 - nature.com
We conducted genome-wide association analyses of over 250,000 participants of European
(EUR) and African (AFR) ancestry from the Million Veteran Program using electronic health …

Genetic approaches to understanding post-traumatic stress disorder

LM Almli, N Fani, AK Smith… - International Journal of …, 2014 - academic.oup.com
Post-traumatic stress disorder (PTSD) is increasingly recognized as both a disorder of
enormous mental health and societal burden, but also as an anxiety disorder that may be …

Recent genetics and epigenetics approaches to PTSD

NP Daskalakis, CM Rijal, C King, LM Huckins… - Current psychiatry …, 2018 - Springer
Abstract Purpose of Review Following a life-threatening traumatic exposure, about 10% of
those exposed are at considerable risk for developing posttraumatic stress disorder (PTSD) …

Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in> 165,000 US veterans

J Gelernter, N Sun, R Polimanti, R Pietrzak… - Nature …, 2019 - nature.com
Post-traumatic stress disorder (PTSD) is a major problem among military veterans and
civilians alike, yet its pathophysiology remains poorly understood. We performed a genome …

Epigenome-wide association study of posttraumatic stress disorder identifies novel loci in US military veterans

JL Montalvo-Ortiz, J Gelernter, Z Cheng… - Translational …, 2022 - nature.com
Posttraumatic stress disorder (PTSD) is a chronic and disabling psychiatric disorder
prevalent in military veterans. Epigenetic mechanisms have been implicated in the etiology …