Schistosomiasis—a century searching for chemotherapeutic drugs

G Ribeiro-dos-Santos, S Verjovski-Almeida… - Parasitology …, 2006 - Springer
Schistosomiasis affects 200 million individuals in underdeveloped and developing regions
and is a growing concern for travelers worldwide. There has been evidence of resistance to …

Chemotherapy for fighting schistosomiasis: past, present and future

P Mäder, GA Rennar, AMP Ventura… - …, 2018 - Wiley Online Library
Chemotherapy based on repeated doses of praziquantel remains the most effective control
strategy against schistosomiasis, a neglected tropical disease caused by platyhelminths of …

Antischistosomal agents: state of art and perspectives

EM Lago, RP Xavier, TR Teixeira, LM Silva… - Future Medicinal …, 2018 - Taylor & Francis
Praziquantel has remained the drug of choice for schistosomiasis chemotherapy for almost
40 years. The pressing need to develop a new antischistosomal drug may necessitate …

Experimentally promising antischistosomal drugs: a review of some drug candidates not reaching the clinical use

RA Abdul-Ghani, N Loutfy, A Hassan - Parasitology research, 2009 - Springer
Schistosomiasis is a chronic parasitic disease affecting about 207 million people in the
world. It still represents a major health problem in many tropical and sub-tropical countries …

[PDF][PDF] Antischistosomal natural compounds: present challenges for new drug screens

J de Moraes - Current topics in tropical medicine, 2012 - repositorio.utp.edu.co
Schistosomiasis, or bilharzias, is a neglected disease that remains a considerable public
health problem in tropical and subtropical regions. This parasitic disease is the most …

Schistosomiasis control: praziquantel forever?

D Cioli, L Pica-Mattoccia, A Basso, A Guidi - Molecular and biochemical …, 2014 - Elsevier
Since no vaccine exists against schistosomiasis and the molluscs acting as intermediate
hosts are not easy to attack, chemotherapy is the main approach for schistosomiasis control …

Chemotherapy of schistosomiasis: present and future

CR Caffrey - Current opinion in chemical biology, 2007 - Elsevier
Schistosomiasis is a chronic parasitic disease in tropical and subtropical regions and is
associated with a variety of clinical syndromes that may lead to severe morbidity. Over the …

Schistosoma mansoni genome project: an update

PT LoVerde, H Hirai, JM Merrick, NH Lee… - Parasitology …, 2004 - Elsevier
A schistosome genome project was initiated by the World Health Organization in 1994 with
the notion that the best prospects for identifying new targets for drugs, vaccines, and …

Schistosomiasis therapeutics: whats in the pipeline?

S Trainor-Moss, F Mutapi - Expert review of clinical pharmacology, 2016 - Taylor & Francis
Schistosomiasis is a debilitating neglected tropical disease caused by schistosome worms.
Global efforts to control schistosomiasis rely predominantly on mass drug administration of …

Schistosomiasis drug therapy and treatment considerations

KC Shekhar - Drugs, 1991 - Springer
Schistosomiasis, a grave and debilitating disease of socioeconomic importance, is
increasing in incidence despite concerted efforts to control and contain the disease in all the …