Objective To investigate the role of matrix metalloproteinase 13 (MMP13; collagenase 3) in
osteoarthritis (OA). Methods OA was surgically induced in the knees of MMP13–knockout …

Objective We have previously reported the upregulation of matrix metalloproteinase 10
(MMP10) following treatment with the procatabolic stimulus of interleukin1 (IL1) and …

Abstract Objective Matrix metalloproteinases (MMPs) have long been considered excellent
targets for osteoarthritis (OA) treatment. However, clinical utility of broadspectrum MMP …

Introduction Osteoarthritis (OA) is a degenerative joint disease affecting a large population of
people. The mechanism of this highly prevalent disease is not fully understood. Currently …

Objective. To show the eventual presence and extent of production of matrix
metalloproteinase 13 (MMP13, or collagenase 3) in rheumatoid synovial tissue samples …

Objective To explore the involvement of synovial macrophages in early cartilage damage in
osteoarthritis (OA), and to identify the role of matrix metalloproteinase 3 (MMP3) in the …

The assembly and degradation of extracellular matrix (ECM) molecules are crucial
processes during bone development. In this study, we show that ECM remodeling is a …

Matrix metalloproteinase-13 (MMP13) is a Zn 2+-dependent protease that catalyzes the
cleavage of type II collagen, the main structural protein in articular cartilage. Excess MMP13 …

Objective To analyze the in vivo compartmental expression of collagenases 1 and 3 (MMP1
and MMP13) in the Hartley guinea pig model of spontaneously occurring osteoarthritis (OA) …

Increased proteolytic activity of matrix metalloproteinases (MMPs) may promote articular
destruction such as occurs in rheumatoid arthritis and osteoarthritis. Recently, we reported …