Chondrogenesis occurs as a result of mesenchymal cell condensation and
chondroprogenitor cell differentiation. Following chondrogenesis, the chondrocytes remain …

Matrix metalloproteinase-13 (collagenase-3), a member of the family of matrix
metalloproteinases (MMPs), plays a major pathological role in the cartilage destruction of …

Objective. To examine, by immunohistochemistry, the localization and distribution of human
collagenase3 in normal, osteoarthritis (OA), and rheumatoid arthritis (RA) cartilage, and to …

OBJECTIVES Matrix metalloproteinases (MMPs) are thought to be major mediators of
cartilage destruction. Osteoarthritis (OA) is characterised by cartilage degradation. This …

Human cartilage is a complex tissue of matrix proteins that vary in amount and orientation
from superficial to deep layers and from loaded to unloaded zones. A major challenge to …

Objective Increased enzymatic activity of matrix metalloproteinases (MMPs) may promote
the progression of rheumatoid arthritis (RA). We undertook this study to investigate the …

Objective Neutrophil accumulation is balanced by both cell infiltration and cell clearance, the
controls of which are pivotal in the pathogenesis of rheumatoid arthritis (RA) and other …

Objective To examine the mechanism of interleukin1 (IL1)–induced collagenase 3 (matrix
metalloproteinase 13 [MMP13]) gene expression in cultured chondrocytes for the purpose …

Extracellular matrix (ECM) remodeling is important during bone development and repair.
Because matrix metalloproteinase 13 (MMP13, collagenase-3) plays a role in long bone …

Matrix metalloproteinases (MMPs) are a large group of enzymes responsible for matrix
degradation. Among them, the family of gelatinases (MMP-2/gelatinase A and MMP …