Membrane-type 1 matrix metalloproteinase (MT1-MMP) is known as an activator of MMP-2.
We reported that the expression of MT1-MMP is a powerful indicator of lymph node …

Membranetype 1 matrix metalloproteinase (MT1MMP) is a presumed activator of MMP2,
which is one of the major proteinases in tumor cell invasion. In this study, we determined the …

Activation of the zymogen of matrix metalloproteinase 2 (proMMP-2, progelatinase A)
possibly is one of the key steps in invasion and metastasis of various human carcinomas …

Expression of matrix metalloproteinases (MMPs) plays an essential role in tumor metastasis
and invasion through the degradation of extracellular matrix (ECM). MT1MMP (membrane …

The mechanisms of the lymph node metastasis remain unclear. We demonstrate the role of
MT1-MMP on the lymph node metastasis using in vivo experimental model of lymph node …

Matrix metalloproteinase (MMP) expression is associated with advanced-stage cancer and
contributes to tumor progression, invasion, and metastasis. Membrane type matrix …

Abstract Matrix metalloproteinase 2 (MMP2) activity is associated with the aggressiveness of
human cancers. Therefore, the mechanisms regulating its activation are of great interest for …

Membrane-type matrix metalloproteinases (MT-MMP) constitute a subfamily of six distinct
membrane-associated MMPs. Although the contribution of MT1-MMP during different steps …

Membrane-type matrix metalloproteinase 1 (MT1-MMP) has been recently described as an
activator of proMMP-2 (MMP-2) which is involved in tumor invasion. We have shown by in …

BACKGROUND Three types of membrane typematrix metalloproteinases (MTMMPs) have
been identified as activators of proMMP2 (gelatinase A/72kilodalton Type IV collagenase) …