Total muscarinic receptor levels, the levels of the subtypes exhibiting high and low affinity for
pirenzepine, and the highand lowaffinity agonist states of the receptor were investigated in …

In Alzheimer's disease (AD), there is a loss of presynaptic cholinergic markers in the
cerebral cortex, but the nature of cholinergic receptor changes is unclear. In this study,[3 …

Of the five subtypes (m1–m5) of muscarinic acetylcholine receptors (mAChR), the m1
subtype is the most abundant in the human cerebral cortex and hippocampus. Impairment of …

We have used quantitative light microscopic autoradiographic techniques to analyze
changes in muscarinic cholinergic receptors in the hippocampus in Alzheimer type dementia …

[30][24][8][16]* p< 0-05, tp 0-01,* p 0-001 compared with cont Number of patients in brackets
in the number of receptors (Bmax (fmoV mg prot.) 473+ 21-1 for controls and 352+ 28-0 for …

Brain muscarinic M1 and M2 binding sites, as defined by their affinity for pirenzepine, were
studied in 24 regions of 3 normal control brains. For each region, the binding of [3 H] QNB, a …

Molecular subtypes of muscarinic receptors (m1–m5) are novel targets for cholinergic
replacement therapies in Alzheimer's disease. However, the status of these receptors in …

Publisher Summary The cholinergic system of the brain has been implicated in memory
function. Evidence for this role is anatomical, physiological and pharmacological. In all …

Postmortem human brain samples were taken from non-neurological controls as well as
demented subjects who died with Alzheimer's disease (AD), multi-infarct dementia (MID), or …

Cholinergic nicotinic and muscarinic receptor binding were measured in post mortem
human brain tissue, using low (nM) concentrations of (3 H)-nicotine to detect predominately …