Muscarinic M2–M5 muscarinic cholinergic receptors were investigated in peripheral blood
lymphocytes of patients with mild cognitive impairment of the Alzheimer's type (MCIAT) …

Loss of cortical nicotinic acetylcholine receptors with high affinity for agonists (20–50%) in
patients with Alzheimer's disease is a common finding. Recent immunochemical analyses …

Muscarinic and nicotinic cholinergic receptors and choline acetyltransferase activity were
studied in postmortem brain tissue from patients with histopathologically confirmed …

The past decade has witnessed an enormous increase in our knowledge of the variety and
complexity of neuropathological and neurochemical changes in Alzheimer's disease …

Postmortem cerebral neocortical and hippocampal samples were taken from patients who
died with dementia of the Alzheimer type (DAT) and individuals without diagnoses of …

Functional imaging techniques offer new possibilities for further understanding of changes in
functional correlates of structural and biological changes in dementia disorders like …

Nicotine promotes transmitter release in the brain by a direct action on presynaptic
terminals. Pharmacological evidence confirms that this action is mediated by nicotinic …

The distribution of muscarinic cholinergic receptors in the human forebrain and cerebellum
was studied in detail by quantitative autoradiography using N-[3 H] methylscopolamine as a …

Cholinergic M1 and M2 muscarinic receptors in aged and young rat brains were studied by
quantitative autoradiography of tritiated QNB in the presence of pirenzepine or carbachol. A …

Cholinergic replacement therapies have yielded little or no clinical improvement in
Alzheimer's disease (AD). Since the number of postsynaptic muscarinic receptors remains …