Cholinergic replacement therapies have yielded little or no clinical improvement in
Alzheimer's disease (AD). Since the number of postsynaptic muscarinic receptors remains …

The vulnerability of the human hippocampal complex to disease, trauma, and aging
indicates the necessity to target this area therapeutically. The distribution and density of …

ObjectivesComparisons were made of nicotinic receptors in 3 major forms of dementia in
old age. Although it is well established the involvement of nicotinic receptors in Alzheimer's …

Neuronal nicotinic acetylcholine receptors are members of the ligand-gated ion channel
superfamily composed of α and β subunits with specific structural, functional and …

Abstract Changes in the cholinergic, serotonergic, noradrenergic, dopaminergic, GABAergic
and somatostatinergic neurons were investigated to determine their roles in Alzheimer's …

The main objective of the present work was to determine whether the regulation of ACh
release by nicotinic and muscarinic autoreceptors is compromised in the aged rat brain. For …

Multiple nicotinic receptors seem to exist in brain as revealed by neurophysiological,
neurochemical, molecular and immunological studies. The mechanisms for their …

Muscarinic cholinergic M1–M5 receptor subtypes were investigated in the cerebellar cortex
of Fischer 344 rats aged 6 (young), 15 (adult) and 22 months (senescent) by combined …

We determined the concentration of the messenger RNA species which encode four (m1–
m4) of the five cloned muscarinic receptors in brains of Alzheimer's disease patients as …

It is now thought that muscarinic acetylcholine receptors are not identical, and the evidence
for this is reviewed briefly, with emphasis on functional studies. In the brain, there is …