The lower brain stem of 25 pathologicallyconfirmed Parkinson's disease (PD) cases was
examined by alpha synuclein immunohistochemistry to characterize pathological …

Abstract Parkinson's disease (PD), one of the most frequent neurodegenerative disorders, is
no longer considered a complex motor disorder characterized by extrapyramidal symptoms …

The identification of the widespread deposition of fibrillized αsynuclein in Lewy bodies and
Lewy neurites in the brains of patients with Parkinson's disease in 1997 has had a profound …

To gain a better understanding of the significance of αsynuclein pathological conditions
during disease progression in Parkinson's disease, we investigated whether 1) nigral …

The synucleinopathy known as sporadic Parkinson's disease (PD) is a multisystem disorder
that severely damages predisposed nerve cell types in circumscribed regions of the human …

Recently, Braak and coworkers proposed a pathologic staging scheme for Parkinson
disease (PD). In this staging, scheme substantia nigra pathology occurs at midstage …

Alpha-synuclein (a-syn) has been implicated in the etiopathogenesis of Parkinson's disease
(PD) based on the observation that mutations in the protein cause a familial form of the …

The search for a satisfactory drug treatment for essential tremor (ET) continues. 1, 2
Lacosamide is a new anticonvulsant drug that has a dual mode of action, enhancing sodium …

Parkinson's disease is a progressive neurodegenerative disorder with multiple factors
contributing to increasing severity of pathology in specific brain regions. The Braak …

Nonmotor manifestations of Parkinson's disease (PD) can begin well before motor PD
begins. It is now clear, from clinical and autopsy studies, that there is significant Lewytype α …