Disruption of circadian rhythms, daily oscillations in biological processes that are regulated
by an endogenous clock, has been linked to tumorigenesis. Normal and malignant tissues …

The Bmal1 gene plays a key role in controlling circadian rhythms. To better understand how
the Bmal1 gene affects tumour growth and the response to anti-cancer drugs, we examined …

The circadian clock generates oscillations in physiology and behavior, known as circadian
rhythms. Links between the circadian clock genes Periods, Bmal1, and Cryptochromes and …

The circadian clock confers daily rhythmicity on many biochemical and physiological
functions and its disruption is associated with increased risks of developing obesity …

The basic helix–loop–helix (bHLH)–PAS domain containing transcription factors CLOCK
and BMAL1 are two major components of the circadian molecular oscillator. It is known that …

Introduction Melanoma is the most lethal type of skin cancer, with increasing incidence and
mortality rates worldwide. Multiple studies have demonstrated a link between cancer …

Purpose: The circadian clock gene Bmal1 is involved in cancer cell proliferation and DNA
damage sensitivity. The aim of this study was to explore the effect of Bmal1 on oxaliplatin …

Background Circadian clocks control cell cycle factors, and circadian disruption promotes
cancer. To address whether enhancing circadian rhythmicity in tumor cells affects cell cycle …

Accumulating evidence indicates a correlation between circadian dysfunction and genomic
instability. However, whether the circadian machinery directly regulates DNA damage repair …

Circadian clock genes regulate cancer development and chemotherapy susceptibility.
Accordingly, chronotherapy based on circadian phenotypes might be applied to improve …