The 'vanishing bone'or inherited osteolysis/arthritis syndromes represent a heterogeneous
group of skeletal disorders characterized by mineralization defects of affected bones and …

Matrix metalloproteinases (MMPs) are capable of processing certain components of bone
tissue, including type 1 collagen, a determinant of the biomechanical properties of bone …

Like other tissue injuries, bone fracture triggers an inflammatory response, which plays an
important role in skeletal repair. Inflammation is believed to have both positive and negative …

The matrix metalloproteinase (MMP) family of extracellular proteases performs crucial roles
in development and repair of the skeleton owing to their ability to remodel the extracellular …

Extracellular matrix production and degradation by bone cells are critical steps in bone
metabolism. Mutations of the gene encoding MMP-2, an extracellular matrix-degrading …

The inherited osteolyses or'vanishing bone'syndromes are a group of rare disorders of
unknown etiology characterized by destruction and resorption of affected bones. The …

The regeneration of adult skeletal tissues requires the timely recruitment of skeletal
progenitor cells to an injury site, the differentiation of these cells into bone or cartilage, and …

Abstract Matrix metalloproteinase 2 (MMP2) is a well‑characterized protein that is
indispensable for extracellular matrix remodeling and other pathological processes, such as …

Multicentric osteolysis with nodulosis and arthropathy (MONA, NAO (OMIM no. 605156)) is
an autosomal recessive member of the 'vanishing bone'syndromes and is notable for the …

Human MMP-1 is a matrix metalloproteinase repeatedly associated with many pathological
conditions, including cancer. Thus, MMP1 overexpression is a poor prognosis marker in a …