[HTML][HTML] A gene co-expression network-based analysis of multiple brain tissues reveals novel genes and molecular pathways underlying major depression
Major depression is a common and severe psychiatric disorder with a highly polygenic
genetic architecture. Genome-wide association studies have successfully identified multiple …
genetic architecture. Genome-wide association studies have successfully identified multiple …
Altered neuro-inflammatory gene expression in hippocampus in major depressive disorder
Abstract Major Depressive Disorder (MDD) is a common psychiatric disorder for which
available medications are often not effective. The high prevalence of MDD and modest …
available medications are often not effective. The high prevalence of MDD and modest …
Using fMRI connectivity to define a treatment-resistant form of post-traumatic stress disorder
A mechanistic understanding of the pathology of psychiatric disorders has been hampered
by extensive heterogeneity in biology, symptoms, and behavior within diagnostic categories …
by extensive heterogeneity in biology, symptoms, and behavior within diagnostic categories …
Post-traumatic stress disorder: clinical and translational neuroscience from cells to circuits
Post-traumatic stress disorder (PTSD) is a maladaptive and debilitating psychiatric disorder,
characterized by re-experiencing, avoidance, negative emotions and thoughts, and …
characterized by re-experiencing, avoidance, negative emotions and thoughts, and …
Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in> 1.2 million individuals highlight new therapeutic directions
Major depressive disorder is the most common neuropsychiatric disorder, affecting 11% of
veterans. Here we report results of a large meta-analysis of depression using data from the …
veterans. Here we report results of a large meta-analysis of depression using data from the …
Genome-wide association study implicates a novel RNA gene, the lincRNA AC068718. 1, as a risk factor for post-traumatic stress disorder in women
Posttraumatic stress disorder (PTSD) is a common and debilitating mental disorder with a
particularly high burden for women. Emerging evidence suggests PTSD may be more …
particularly high burden for women. Emerging evidence suggests PTSD may be more …
Cortical volume abnormalities in posttraumatic stress disorder: an ENIGMA-psychiatric genomics consortium PTSD workgroup mega-analysis
X Wang, H Xie, T Chen, AS Cotton, LE Salminen… - Molecular …, 2021 - nature.com
Studies of posttraumatic stress disorder (PTSD) report volume abnormalities in multiple
regions of the cerebral cortex. However, findings for many regions, particularly regions …
regions of the cerebral cortex. However, findings for many regions, particularly regions …
[HTML][HTML] A double-hit of stress and low-grade inflammation on functional brain network mediates posttraumatic stress symptoms
Growing evidence indicates a reciprocal relationship between low-grade systemic
inflammation and stress exposure towards increased vulnerability to neuropsychiatric …
inflammation and stress exposure towards increased vulnerability to neuropsychiatric …
Brain proteome-wide association study implicates novel proteins in depression pathogenesis
Depression is a common condition, but current treatments are only effective in a subset of
individuals. To identify new treatment targets, we integrated depression genome-wide …
individuals. To identify new treatment targets, we integrated depression genome-wide …
Focal brain damage protects against post-traumatic stress disorder in combat veterans
Post-traumatic stress disorder (PTSD) is an often debilitating mental illness that is
characterized by recurrent distressing memories of traumatic events. PTSD is associated …
characterized by recurrent distressing memories of traumatic events. PTSD is associated …