The effects of CACNA1C gene polymorphism on prefrontal cortex in both schizophrenia patients and healthy controls

Z Zhang, Y Wang, Q Zhang, W Zhao, X Chen… - Schizophrenia …, 2019 - Elsevier
CACNA1C gene polymorphism rs2007044 has been reported to be associated with
schizophrenia, but its underlying brain mechanism is not clear. First, we conducted an …

Role of CACNA1C gene polymorphisms and protein expressions in the pathogenesis of schizophrenia: a case-control study in a Chinese population

SY Zhang, Q Hu, T Tang, C Liu, CC Li, XG Yang… - Neurological …, 2017 - Springer
The study aimed to investigate the correlations of CACNA1C genetic polymorphisms and
protein expression with the pathogenesis of schizophrenia in a Chinese population. This …

Effects of the CACNA1C risk allele on neurocognition in patients with schizophrenia and healthy individuals

H Hori, N Yamamoto, T Fujii, T Teraishi, D Sasayama… - Scientific reports, 2012 - nature.com
Recent genetic association studies have identified the A-allele of rs1006737 within
CACNA1C as a risk factor for schizophrenia as well as mood disorders. Some evidence …

Genetic variation in CACNA1C affects brain circuitries related to mental illness

KL Bigos, VS Mattay, JH Callicott… - Archives of general …, 2010 - jamanetwork.com
Context TheCACNA1Cgene (α-1C subunit of the L-type voltage-gated calcium channel) has
been identified as a risk gene for bipolar disorder and schizophrenia, but the mechanism of …

The effects of a genome-wide supported variant in the CACNA1C gene on cortical morphology in schizophrenia patients and healthy subjects

F Zheng, Y Cui, H Yan, B Liu, T Jiang - Scientific Reports, 2016 - nature.com
Schizophrenia is a highly heritable disorder with multiple susceptibility genes. Previously,
we identified CACNA1C rs2007044 as a new risk locus for schizophrenia, with the minor …

A common CACNA1C gene risk variant has sex-dependent effects on behavioral traits and brain functional activity

H Takeuchi, H Tomita, Y Taki, Y Kikuchi, C Ono… - Cerebral …, 2019 - academic.oup.com
Genome-wide association studies have suggested that allelic variations in the CACNA1C
gene confer susceptibility to schizophrenia and bipolar disorder only in women. Here we …

CACNA1C gene rs1006737 polymorphism affects cognitive performance in Chinese han schizophrenia

M Chen, Q Jiang, L Zhang - Neuropsychiatric Disease and …, 2022 - Taylor & Francis
Objective To investigate the relationship between L-type calcium channel α1C subunit
(CACNA1C) gene polymorphism and schizophrenia (SCZ) and cognitive function in the Han …

An independent, replicable, functional and significant risk variant block at intron 3 of CACNA1C for schizophrenia

Z Wang, W Chen, Y Cao, Y Dou, Y Fu… - Australian & New …, 2022 - journals.sagepub.com
Objectives: Genome-wide association studies have identified a significant risk gene,
CACNA1C, for schizophrenia. In this study, we comprehensively investigated a large set of …

Association of rs1006737 in CACNA1C with alterations in prefrontal activation and frontohippocampal connectivity

FM Paulus, J Bedenbender, S Krach… - Human brain …, 2014 - Wiley Online Library
Background: Genomewide association studies have identified the rs1006737 single
nucleotide polymorphism (SNP) in the CACNA1C gene as a susceptibility locus for …

The impact of CACNA1C allelic variation on regional gray matter volume in Chinese population

L Huang, Y Mo, X Sun, H Yu, H Li… - American Journal of …, 2016 - Wiley Online Library
The SNP rs1006737 in CACNA1C gene has been significantly associated with psychiatric
disorders (eg, schizophrenia and bipolar disorder) in European populations. In Han …