Celastrol as a pentacyclic triterpenoid with chemopreventive properties

P Yadav, V Jaswal, A Sharma, D Kashyap… - Pharmaceutical …, 2018 - Taylor & Francis
Celastrol is a highly investigated anticancer moiety. It is a pentacyclic triterpenoid, isolated
several decades ago with promising role in chemoprevention. Celastrol has been found to …

Molecular targets of celastrol in cancer: Recent trends and advancements

D Kashyap, A Sharma, HS Tuli, K Sak… - Critical Reviews in …, 2018 - Elsevier
Despite the advancement in the well-equipped and sophisticated laboratories and facilities,
cancer remains to be a major cause of death worldwide. Consequently, further investigation …

Celastrol in cancer therapy: Recent developments, challenges and prospects

HY Lim, PS Ong, L Wang, A Goel, L Ding, ALA Wong… - Cancer Letters, 2021 - Elsevier
Cancer is one of the world's biggest healthcare burdens and despite the current
advancements made in treatment plans, the outcomes for oncology patients have yet to …

[HTML][HTML] Celastrol as an emerging anticancer agent: Current status, challenges and therapeutic strategies

C Wang, S Dai, X Zhao, Y Zhang, L Gong, K Fu… - Biomedicine & …, 2023 - Elsevier
Celastrol is a pentacyclic triterpenoid extracted from the traditional Chinese medicine
Tripterygium wilfordii Hook F., which has multiple pharmacological activities. In particular …

[HTML][HTML] Molecular modulators of celastrol as the keystones for its diverse pharmacological activities

SW Ng, Y Chan, DK Chellappan… - Biomedicine & …, 2019 - Elsevier
In the recent years, much attention has been focused on identifying bioactive compounds
from medicinal plants that could be employed in therapeutics, which is attributed to their …

Novel celastrol derivatives with improved selectivity and enhanced antitumour activity: Design, synthesis and biological evaluation

SAC Figueiredo, JAR Salvador, R Cortes… - European Journal of …, 2017 - Elsevier
Celastrol is one of the most active antitumour compounds among the natural triterpenoids. It
has been reported to be highly active against a wide variety of tumours and to affect multiple …

Celastrol and its role in controlling chronic diseases

SH Venkatesha, KD Moudgil - Anti-inflammatory Nutraceuticals and …, 2016 - Springer
Celastrol, a triterpenoid derived from traditional Chinese medicinal plants, has anti-
inflammatory, antioxidant, and anticancer activities. Celastrol has shown …

Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways

R Kannaiyan, KA Manu, L Chen, F Li, P Rajendran… - Apoptosis, 2011 - Springer
Celastrol, a plant triterpene has attracted great interest recently, especially for its potential
anti-inflammatory and anti-cancer activities. In the present report, we investigated the effect …

Celastrol: a review of useful strategies overcoming its limitation in anticancer application

J Shi, J Li, Z Xu, L Chen, R Luo, C Zhang… - Frontiers in …, 2020 - frontiersin.org
Celastrol, a natural bioactive ingredient derived from Tripterygium wilfordii Hook F, exhibits
significant broad-spectrum anticancer activities for the treatment of a variety of cancers …

Quantitative chemical proteomics reveals anti-cancer targets of Celastrol in HCT116 human colon cancer cells

X Zhang, J Zhou, Y Zhu, YK Wong, D Liu, P Gao, Q Lin… - Phytomedicine, 2022 - Elsevier
Abstract Background Celastrol (Cel) is a naturally-derived compound with anti-cancer
properties and exerts beneficial effects against various diseases. Although an extensive …