Celastrol as a pentacyclic triterpenoid with chemopreventive properties
Celastrol is a highly investigated anticancer moiety. It is a pentacyclic triterpenoid, isolated
several decades ago with promising role in chemoprevention. Celastrol has been found to …
several decades ago with promising role in chemoprevention. Celastrol has been found to …
Molecular targets of celastrol in cancer: Recent trends and advancements
Despite the advancement in the well-equipped and sophisticated laboratories and facilities,
cancer remains to be a major cause of death worldwide. Consequently, further investigation …
cancer remains to be a major cause of death worldwide. Consequently, further investigation …
Celastrol in cancer therapy: Recent developments, challenges and prospects
Cancer is one of the world's biggest healthcare burdens and despite the current
advancements made in treatment plans, the outcomes for oncology patients have yet to …
advancements made in treatment plans, the outcomes for oncology patients have yet to …
[HTML][HTML] Celastrol as an emerging anticancer agent: Current status, challenges and therapeutic strategies
C Wang, S Dai, X Zhao, Y Zhang, L Gong, K Fu… - Biomedicine & …, 2023 - Elsevier
Celastrol is a pentacyclic triterpenoid extracted from the traditional Chinese medicine
Tripterygium wilfordii Hook F., which has multiple pharmacological activities. In particular …
Tripterygium wilfordii Hook F., which has multiple pharmacological activities. In particular …
[HTML][HTML] Molecular modulators of celastrol as the keystones for its diverse pharmacological activities
In the recent years, much attention has been focused on identifying bioactive compounds
from medicinal plants that could be employed in therapeutics, which is attributed to their …
from medicinal plants that could be employed in therapeutics, which is attributed to their …
Novel celastrol derivatives with improved selectivity and enhanced antitumour activity: Design, synthesis and biological evaluation
SAC Figueiredo, JAR Salvador, R Cortes… - European Journal of …, 2017 - Elsevier
Celastrol is one of the most active antitumour compounds among the natural triterpenoids. It
has been reported to be highly active against a wide variety of tumours and to affect multiple …
has been reported to be highly active against a wide variety of tumours and to affect multiple …
Celastrol and its role in controlling chronic diseases
SH Venkatesha, KD Moudgil - Anti-inflammatory Nutraceuticals and …, 2016 - Springer
Celastrol, a triterpenoid derived from traditional Chinese medicinal plants, has anti-
inflammatory, antioxidant, and anticancer activities. Celastrol has shown …
inflammatory, antioxidant, and anticancer activities. Celastrol has shown …
Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways
Celastrol, a plant triterpene has attracted great interest recently, especially for its potential
anti-inflammatory and anti-cancer activities. In the present report, we investigated the effect …
anti-inflammatory and anti-cancer activities. In the present report, we investigated the effect …
Celastrol: a review of useful strategies overcoming its limitation in anticancer application
J Shi, J Li, Z Xu, L Chen, R Luo, C Zhang… - Frontiers in …, 2020 - frontiersin.org
Celastrol, a natural bioactive ingredient derived from Tripterygium wilfordii Hook F, exhibits
significant broad-spectrum anticancer activities for the treatment of a variety of cancers …
significant broad-spectrum anticancer activities for the treatment of a variety of cancers …
Quantitative chemical proteomics reveals anti-cancer targets of Celastrol in HCT116 human colon cancer cells
X Zhang, J Zhou, Y Zhu, YK Wong, D Liu, P Gao, Q Lin… - Phytomedicine, 2022 - Elsevier
Abstract Background Celastrol (Cel) is a naturally-derived compound with anti-cancer
properties and exerts beneficial effects against various diseases. Although an extensive …
properties and exerts beneficial effects against various diseases. Although an extensive …