… Finally, of what relevance is PBL gene expression for a disorder primarily associated with
the brain? In this study we identify innate immunity and IFN signalling genes whose …

… disorders but instead will focus on those, particularly depression, post-traumatic stress
disorder, and bipolar disorder … by elements of the innate immune system (“neuroinflammation”). …

… system, which is the phylogenetically oldest immune system, refers to the first-… innate immune
system [6]. In this study, Nie et al. investigated the role of TLR2 and TLR4 in repeated stress…

… , such as depression, schizophrenia, autism spectrum disorders, and post-traumatic stress
disorder. The present review summarizes and discusses the main evidence linking the …

Posttraumatic stress disorder (PTSD) is a complex psychiatric disorder that can develop
following exposure to traumatic events. The Psychiatric Genomics Consortium PTSD group (PGC…

… innate immune signaling as a critical link between stress (… innate immune response in
disease pathology, and recent findings indicating the innate immune response to chronic stresses …

… insight into the mechanisms underlying posttraumatic stress disorder (PTSD) and comorbid
… a dysregulation of genes associated with the innate immune, neuroendocrine, and NF-κB …

… of major depressive disorder, schizophrenia and post-traumatic stress disorder, amongst …
progression of neuropsychiatric disorders. Microglia, the resident innate immune cells of the …

… with the innate immune module … innate immunity may be involved in the progression of
PTSD, yet also identified candidate MRs driving the disease progression in the innate immunity …

… stress, we find that PS induces the transcriptomic and epigenomic reprogramming of
monocytes, enhancing their innate immune … gene expression in high-stress mice and humans, …