Recent progress of bioactivities, mechanisms of action, total synthesis, structural modifications and structure-activity relationships of indole derivatives: a review

T Li, H Xu - Mini Reviews in Medicinal Chemistry, 2022 - ingentaconnect.com
… This mini-review has summarized the recent developments from 2018 to 2020 on mechanisms
of action, total synthesis, structural modifications, and structure-activity relationships of …

Focus on modified microcins: structural features and mechanisms of action

D Destoumieux-Garzón, J Peduzzi, S Rebuffat - Biochimie, 2002 - Elsevier
modified microcins that show very original structures. We present an updated overview on the
structures and mechanisms of action … , which include specific modification enzymes, export …

Biosynthesis, total synthesis, structural modifications, bioactivity, and mechanism of action of the quinonemethide triterpenoid celastrol

Y Lu, Y Liu, J Zhou, D Li, W Gao - Medicinal research reviews, 2021 - Wiley Online Library
… To search for druglike derivatives, several structurally modified compounds were … ,
total synthesis, structural modifications, bioactivity, and mechanism of action of celastrol. We …

Vancomycin C-terminus guanidine modifications and further insights into an added mechanism of action imparted by a peripheral structural modification

ZC Wu, MD Cameron, DL Boger - ACS infectious diseases, 2020 - ACS Publications
… of this newly introduced mechanism of action by the guanidine modification, we conducted …
of the two mechanisms of action attributable to the CBP and guanidine modifications requires …

What structural features determine repair enzyme specificity and mechanism in chemically modified DNA?

B Singer, B Hang - Chemical research in toxicology, 1997 - ACS Publications
… a base modification (eg, pBQ-dC) can cause a local structuralmodified an AP site and
found that an urea residue or O-alkylhydroxylamines did not prevent 5‘-cleavage of the modified

The structural modification of natural products for novel drug discovery

H Yao, J Liu, S Xu, Z Zhu, J Xu - Expert opinion on drug discovery, 2017 - Taylor & Francis
… of structural modifications of NPs in drug discovery, including deciphering the mode of
actions, overcoming multidrug resistance, repurposing of drugs, structural simplification, …

Tubulin posttranslational modifications: enzymes and their mechanisms of action

TH MacRae - European Journal of Biochemistry, 1997 - Wiley Online Library
… phase, but its action on microtubules within these structures is uncertain. As another example
of tyrosine kinase activity, a-tubulin and p-tubulin are modified during monocytic differentia…

Matrine: Bioactivities and structural modifications

J Huang, H Xu - Current Topics in Medicinal Chemistry, 2016 - ingentaconnect.com
… Especially the mechanism of action of anticancer … tural modifications of matrine and its
derivatives are summarized from 2010 to 2015. Additionally, the mechanism of action and structure

Alteration of nucleosome structure as a mechanism of transcriptional regulation

JL Workman, RE Kingston - Annual review of biochemistry, 1998 - annualreviews.org
… The direct modification of nucleosome structure bythese … areless structured and extend out
of the central structured … we relate these modifications tochanges in the structural properties of …

Anti-cancer peptides: classification, mechanism of action, reconstruction and modification

M Xie, D Liu, Y Yang - Open biology, 2020 - royalsocietypublishing.org
… side chain modification. After summarizing the classification and mechanism of action of ACPs,
… and progress about their reconstruction and modification. The information collected here …