A convergent synthesis of cryptophycins has been developed in which (5S,6R)-5-hydroxy-6-methyl-8-phenylocta-2(E),7(E)-dienoic
acid (A) is coupled with an amino acid segment (B). …

… synthesis of tert-butyl (5S,6R,2E,7E)-5-[(tert-butyldimethylsilyl)oxy]-6-methyl-8-phenyl-2,7-octadienoate,
a major component of the cryptophycins… methyl of the cryptophycins. The second …

… -diCl C10 analogues of cryptophycin-24 were prepared via total synthesis and tested in vitro
… parent compound cryptophycin-24. Substitution of the 4‘-MeO group in cryptophycin-24 with …

… The first representative of these depsipeptides, cryptophycin 1 (1), was isolated in 1990 … of
cryptophycin 24 (3), also known as arenastatin A, was described.5 Initially, cryptophycin 1 was …

… analogs was cryptophycin-24, … to total synthesis for the preparation of cryptophycins. Although
Moore and co-workers have recently completed an elegant total synthesis of cryptophycin …

… The chloro derivative 24 was obtained in 68% yield from 15. The synthesis of 1 and
Cryptophycin C was easily completed by first coupling 24 with the appropriate subunit A (9 or 20). …

… gave carboxylic acid 23.19 L-leucic acid was converted to allyl ester 24 in 93% yield under
phase-transfer conditions, by exposing it to a mixture … The coupling reaction of 23 with 24 was …

… to synthesize partially fluorinated analogues of cryptophycins. The depsipeptidic character
of the cryptophycins suggests four different fragments to be assembled in the total synthesis, …

… to develop as simple a cryptophycin synthesis as possible, we … /methanol at 40C for 24 h
led to cryptophycin 1 in 70% overall … in the context of the total synthesis of cryptophycin 52, a …

… to our knowledge, no synthesis of a C3 epimer of any cryptophycin has been … synthesis and
evaluation of C3-epi-cryptophycin-24 (5, Figure 2), C3-epi-m-chlorobenzyl-cryptophycin-24 (6…