BRAF Mutation in Papillary Thyroid Cancer: Pathogenic Role, Molecular Bases, and Clinical Implications

M Xing - Endocrine reviews, 2007 - academic.oup.com
… Thus, the T1799A mutation is virtually the only BRAF mutation identified in thyroid cancer (…
in familial thyroid cancer (49, 50). A striking finding on BRAF mutation in thyroid cancer is its …

Prognostic utility of BRAF mutation in papillary thyroid cancer

M Xing - Molecular and cellular endocrinology, 2010 - Elsevier
Papillary thyroid cancer (PTC) is a common endocrine malignancy that frequently harbors the
oncogenic T1799A BRAF mutation. As a … In PTC, BRAF mutation is closely associated with …

BRAF mutation in papillary thyroid cancer and its value in tailoring initial treatment: a systematic review and meta-analysis

RP Tufano, GV Teixeira, J Bishop, KA Carson, M Xing - Medicine, 2012 - journals.lww.com
… of thyroid cancer, papillary thyroid cancer (PTC)—a tumor type … the association of BRAF
mutation with PTC recurrence or … to investigate correlations of BRAF mutation status with PTC …

BRAF mutation in papillary thyroid carcinoma

Y Cohen, M Xing, E Mambo, Z Guo… - … the National Cancer …, 2003 - academic.oup.com
… analyzed nine common thyroid cell lines (… BRAF mutation in six (67%) of the nine lines. We
also completely sequenced exons 11 and 15 in all T1796A-negative papillary thyroid cancers

BRAF mutation predicts a poorer clinical prognosis for papillary thyroid cancer

M Xing, WH Westra, RP Tufano, Y Cohen… - The Journal of …, 2005 - academic.oup.com
… shown that this BRAF mutation occurs in papillary thyroid cancer (PTC) … BRAF mutation
occurs exclusively in PTC and PTC-derived anaplastic thyroid cancers but not in normal thyroid

Clinical Implication of Hot Spot BRAF Mutation, V599E, in Papillary Thyroid Cancers

H Namba, M Nakashima, T Hayashi… - The Journal of …, 2003 - academic.oup.com
… human thyroid cancers. We detected BRAF mutation, V599E, in four of six human thyroid
cancer cell lines and in 51 of 207 thyroid tumor tissues. The correlation analysis using various …

The prevalence and prognostic value of BRAF mutation in thyroid cancer

E Kebebew, J Weng, J Bauer, G Ranvier… - Annals of …, 2007 - journals.lww.com
… of BRAF mutation among thyroid cancer histologic subtypes and determine the association
of BRAF mutation with indicators of poor prognosis for papillary thyroid cancer and patient …

Optimizing surgical treatment of papillary thyroid carcinoma associated with BRAF mutation

L Yip, MN Nikiforova, SE Carty, JH Yim, MT Stang… - Surgery, 2009 - Elsevier
… is the most common genetic alteration found in papillary thyroid carcinoma (PTC) and is
associated with extrathyroidal extension, lymph node metastasis, and tumor recurrence. It is not …

BRAF mutation in papillary thyroid carcinoma: pathogenic role and clinical implications

KT Tang, CH Lee - Journal of the chinese medical association, 2010 - journals.lww.com
… the most rapidly increasing cancer among women and the … thyroid cancers are classified
into papillary thyroid cancer (PTC), follicular thyroid cancer (FTC), and anaplastic thyroid cancer

The BRAF mutation is useful for prediction of clinical recurrence in low‐risk patients with conventional papillary thyroid carcinoma

TY Kim, WB Kim, YS Rhee, JY Song… - Clinical …, 2006 - Wiley Online Library
Background The activating BRAF V600E mutation is the most common genetic alteration
reported in papillary thyroid carcinoma (PTC). While some reports suggest the BRAF V600E …