… main protease (M pro ) of the SARS-CoV-2 is a crucial therapeutic target due to its critical
function in virus replication. The α-ketoamide … and SARS-CoV-2 main proteases, anti-SARS-…

… a complete overview of the α-ketoamide inhibitor, we optimized a simple α-ketoamide N-methyl-2-oxopropanamide.
We find that there are three possible isomers of α-ketoamide C 1 , C …

… and synthesized peptidomimetic α-ketoamides as broad-spectrum inhibitors of the main
proteases of betacoronaviruses and alphacoronaviruses as well as the 3C proteases of …

… In this paper, we have used the case of an α-ketoamide … The main protease of SARS-CoV-2
contains a cysteine (… There are some proposals that the dyads of cysteine protease systems …

… The α-ketoamide 13b ligand bound to the protease with a GlideScore of -8.8 kcal/mol to the
… For binding to the dimer structure of the protease (Table 2), α-ketoamide 13b bound with …

… Docking models indicated that α-keto oxygen and the amide oxygen of α-ketoamide head
… -2 main protease, which might suggest a possible advantage of α-ketoamide compared with …

… Previously, we have designed and synthesized peptidomimetic a-ketoamides as broadspectrum
inhibitors of the main proteases of betacoronaviruses and alphacoronaviruses as well …

… In the enzyme- and/or cell-based studies set up to evaluate the capability of these derivatives
to inhibit viral replication or viral protease activity, the α-ketoamide 100 showed IC 50 …

… α-ketoamide inhibitor (Lig13b) is available (PDB ID:6Y2G ). Using 6Y2G and the prior knowledge
that protease … docking, we identified Isavuconazonium, a ketoamide inhibitor (α-KI) and …

… Herein, we report the discovery of a series of α-ketoamide … α-ketoamide-containing
inhibitor (27h) of SARS-CoV-2 M pro with an action mode different from other known α-ketoamide-…