… α,α disubstituted, N-methyl and α-hydroxy derivatives, but no β-amino acids. We show that
over 50 unnatural amino acids can be incorporated into peptides … for α-methyl substituted AAs …

… unnatural amino acids in the fields of peptide and combinatorial chemistry is universal and
captures the imagination of many synthetic and peptide … -substitutions of the amino group in α-…

… between the Puma α-peptide and its α/β-peptide mimic was that the unnatural backbone lost
… Remarkably, a single α→β cyc substitution (ACBC) resulted in an α/β-peptide with potent …

… This ratio originally drew our interest because of the hypothesis that an αγααβα hexad
pattern could provide a basis for α-helix-mimetic oligomers in which the unnatural β and γ …

… When both C α and C β are alkyl-substituted, we can have like [(R,R) or (S,S) configuration]
and unlike [(R,S) or (S,R)] β 2,3 -AAs. Other types of di- and trisubstituted β-AAs are defined …

… of the peptides are presented in Figure 3 and the α-helical … series of peptide derivatives
containing D- and unnatural amino … Dab and Dap are unnatural basic amino acids that occur in a …

… (2) In these cases, the simple backbone substitutions provided little in the way of strict steric
… side chain in the α-peptide subunit, while in the constrained γ- and α/γ-peptides and in the …

… α 32 P]-AMP. Following aminoacylation, the labeled tRNA is digested with nuclease P1 and
the liberated aminoacyl-[α … to the fully substituted analogue peptide and several minor peaks. …

… that different substitutions resulted in different effects on the peptide conformation … substitutions
in the middle of the amino acid sequence destroyed the α-helical structure of the peptide …

… peptides investigated to date with those of a-peptides (peptides consisting of natural and
unnatural … containing no ring and having identical configuration and substitution pattern of the …