… be more on the neuritic transport capabilities of mitochondria than on their direct functional
destruction, which is supported by our finding of a more pronounced axonal degeneration in …

… and is preferentially accumulated in dopaminergic neurons (23). … dopaminergic degeneration
and α-synuclein aggregation and … dopaminergic degeneration and formation of α-synuclein-…

… nature of α-synuclein and its complex aggregation … α-synuclein aggregation, disrupts mature
amyloid fibrils, prevents fibril propagation, and abolishes the degeneration of dopaminergic …

… α-Syn protofibrils and drive the neurons into a vicious cycle, which will finally result in the
selective degeneration of the dopaminergic … vicious cycle among aggregated αSyn protofibrils, …

… α-syn misfolding and associated dopaminergic degeneration in a rat model of PD. Hsp104’s
ability to prevent and reverse pathogenic protein aggregation … protein aggregation diseases. …

… of DA and its oxidative intermediates in modulating the aggregation pathways of α-syn. …
α-syn and DA in cells and dopaminergic neurons [62]. DA induces the aggregation of both WT α-…

… by progressive degeneration of pigmented … α-synuclein aggregates shows strong
cytoplasmic immunoreactivity for TH. (BD) Pigmented neurons containing α-synuclein aggregates …

… α-Syn aggregation and actual aggregated species responsible for the degeneration of
dopaminergic … Despite the fact that α-Syn aggregation in LBs and LNs is crucial and mutations of …

… Various mechanisms for in vitro and in vivo α-synuclein aggregation and neurotoxicity are
… susceptible to dopamine toxicity than those overexpressing WT α-synuclein. Cytoplasmic …

… Our findings also demonstrate that dopamine modifies α-synuclein aggregation in vivo,
resulting in oligomer conformations that are biochemically and structurally similar to neurotoxic …