… Alpha synuclein (α-SN) is a ubiquitous protein that is especially abundant … Parkinson's
disease (PD), Alzheimer's disease, and other neurodegenerative disorders. Here, we show that α-…

α-Synuclein is a presynaptic neuronal protein that is linked genetically and neuropathologically
to Parkinson's disease (PD). α-Synuclein may contribute to PD pathogenesis in a …

Substantial evidence links α-synuclein, a small highly conserved presynaptic protein with
unknown function, to both familial and sporadic Parkinson's disease (PD). α-Synuclein has …

… Interest in α‐syn has increased dramatically after the discovery of a relationship between its
… diseases, including Parkinson's disease (PD). The physiological functions of α‐syn remain …

… α-synuclein mutations were shown to be associated with autosomal-dominant Parkinson's
disease … However, the discovery that α-synuclein is a major component of Lewy bodies and …

… yielded remarkable insights into the role of α-synuclein in neurodegeneration, and, today, …
role of α-synuclein in the pathogenesis of Parkinson’s disease. This is because α-synuclein is …

… Parkinson's disease (PD) is a common neurodegenerative disorder, characterized pathologically
by the presence of α-synuclein (α-… , highlighting the need for disease-specific and early …

… various α-synuclein … in Parkinson’s disease patients. This review summarizes our current
knowledge of the pathogenetic dysfunction of α-synuclein associated with Parkinson’s disease …

… neurodegenerative disease. In this review, we explore the evidence for cell-to-cell
transmission of pathological α-synuclein, the current understanding of how pathological α-synuclein …

… clinical impact of α-synuclein locus multiplications, and the implications that this has for
Parkinson's disease pathogenesis. Finally, we discuss potential strategies for disease-modifying …