Monomeric alpha-synuclein (aSyn) is a well characterised protein that importantly binds to
lipids. aSyn monomers assemble into amyloid fibrils which are localised to lipids and
organelles in insoluble structures found in Parkinson's disease patient's brains. Previous
work to address pathological aSyn-lipid interactions has focused on using synthetic lipid
membranes, which lack the complexity of physiological lipid membranes. Here, we use
physiological membranes in the form of synaptic vesicles (SV) isolated from rodent brain to …

Monomeric alpha-synuclein (aSyn) is a well characterised as a lipid binding protein. aSyn is
known to form amyloid fibrils which are also localised with lipids and organelles in so called
Lewy bodies, insoluble structures found in Parkinson's disease patient's brains. It is still
unclear under which conditions the aSyn-lipid interaction can start to become pathological.
Previous work to address pathological interactions has focused on using synthetic lipid
membranes, which lack the complexity of physiological lipid membranes which not only …