… the role of α-cells in β-cell generation and regeneration. We … in adult islets to promote β-cell
regeneration. β-cells appear … the adult pancreas in response to β-cell injuries. Plasticity of α-…

… The precise identification of the mechanisms involved in the maintenance of β-cell mass
under different conditions could offer new hints to help generating new β-cells as a cell …

… the precise processes of β-cell differentiation and trans-… in understanding β-cell generation
and regeneration, in vivo … delineated the mechanism of α-cell identity maintenance by …

… of islet regeneration by any … islet regeneration, with different emphasis depending on the
injury and on the species. We will discuss the state of our knowledge of β cell/islet regeneration …

… of Pax1 and Mafα, or targeted disruption of α cell-specific TFs such as Dnmt1 and Arx, can
… Moreover, technologies for generation of insulin producing cells derived from iPS cells has …

… of the early β-cell transcription factor PAX4, or knockout of the α-cell transcription factor ARX…
seen significant efforts to establish protocols for generation of functional β-cells from human …

… Thus, regenerative medicine, including generation of … Thus, cyclin D2 plays a key role in
β-cell replication, which … α-cells to β-cells decreases the α-cell population, which might cause the …

… Unfortunately, these efforts have hitherto not allowed the generation of fully functional β-cells. …
for the repression of α-cell lineage-determining genes in order to maintain a pancreatic …

… , either through β cell regeneration in vivo or by generating new β … associated with in vivo
β cell regeneration, which can be … Pax4 and inhibition of the α cell gene Arx in mice appear to …

… diabetic mice, generating a functional β-cell mass to restore … of acinar cells toward β-cell
fate during regeneration in vivo, … Old age or senescence does not seem to alter α-cell plasticity…