Dual bronchodilation for the treatment of COPD: from bench to bedside

M Cazzola, C Page, P Rogliani… - British Journal of …, 2022 - Wiley Online Library
… , is the use of the dual bronchodilation, which is a treatment that … (LAMA) with a long-acting
β 2 -agonist (LABA), rather than a … with dual bronchodilation when they are already taking a β-…

[HTML][HTML] Triple therapy versus dual bronchodilation and inhaled corticosteroids/long-acting β-agonists in COPD: accumulating evidence from network meta-analyses

M Cazzola, L Calzetta, P Rogliani, MG Matera - Pulmonary Therapy, 2019 - Springer
… the role of triple therapy containing a long-acting β-agonist (LABA), a long-acting muscarinic
… population, supporting the role of dual bronchodilation therapy for the treatment of COPD. …

Treatment of chronic obstructive pulmonary disease by dual bronchodilation with coformulation of indacaterol/glycopyrronium

G Pelaia, R Maselli, MG Matera - Pharmacology, 2015 - karger.com
… These drugs include β 2-adrenergic agonists and antago… on the high density of β 2-adrenergic
receptors (β 2-ARs) … effective bronchodilators are long-acting β 2adrenergic agonists (…

Considerations for new dual-acting bronchodilator treatments for chronic obstructive pulmonary disease

J de Miguel-Díez, R Jiménez-García - Expert Opinion on …, 2014 - Taylor & Francis
… The concept of dual bronchodilation can currently be achieved with a … dual-acting
bronchodilator treatments for COPD, muscarinic receptor antagonist and β 2 -adrenoceptor agonist (…

Dual LABA/LAMA bronchodilators in chronic obstructive pulmonary disease: why, when, and how

L Calzetta, MG Matera, P Rogliani… - Expert Review of …, 2018 - Taylor & Francis
Dual bronchodilation therapy is the cornerstone for the treatment of chronic obstructive …
Combining a long-acting β 2 adrenoceptor (β 2 -AR) agonist (LABA) with a long-acting …

A systematic review with meta-analysis of dual bronchodilation with LAMA/LABA for the treatment of stable COPD

L Calzetta, P Rogliani, MG Matera, M Cazzola - Chest, 2016 - Elsevier
… The wide availability of long-acting muscarinic antagonist (LAMA)/long-acting β2-agonist
(… In the meanwhile, we believe it is only proper to consider that dual bronchodilation is better …

When is dual bronchodilation indicated in COPD?

M Thomas, DMG Halpin… - International Journal of …, 2017 - Taylor & Francis
Dual bronchodilation with a long-acting β 2 -agonist and long-acting muscarinic antagonist
may be more effective treatment for some of these patients, with the aim of improving …

Dual bronchodilation in COPD: lung function and patient-reported outcomes–a review

D Price, A Østrem, M Thomas… - International journal of …, 2016 - Taylor & Francis
… Several fixed-dose combinations (FDCs) of long-acting bronchodilators (a long-acting
muscarinic antagonist [LAMA] plus a long-acting β 2 -agonist [LABA]) are available for the …

Double bronchodilation in chronic obstructive pulmonary disease: a crude analysis from a systematic review

JL Lopez-Campos, C Calero-Acuña… - … Journal of Chronic …, 2017 - Taylor & Francis
… ) and a long-acting β 2 -agonist (LABA) in a … double bronchodilation for the treatment of
COPD, with a specific focus on its efficacy versus placebo and/or monotherapy bronchodilation

Dual-pharmacology bronchodilators for the treatment of COPD

JR Jacobsen, J Aiyar, S Hegde, AD Hughes… - New Drugs and Targets …, 2010 - karger.com
… In keeping with this paradox, we have found that cells expressing M 3 and β 2 receptors (but
not M 2 and β 2 receptors) show enhanced potency to muscarinic agonists compared to …