… amyloid misfolding, based on our structural … amyloid intermediates. Our study provides
encouraging prospects for the molecular structural characterization of other amyloid intermediates…

… structural analysis for amyloid intermediate species. This study also reveals that structurally
homogeneous β-sheet intermediates … and supramolecular structures of this intermediate will …

… These intermediate structures can include Aβ dimers, … quaternary structure, protofilament
organization and packing of β-… interest, including the structural polymorphism of amyloid fibrils, …

… polypeptide show that a decrease in the β-aggregation propensity results in a larger …
structure of the final fibril. Protofibrillar intermediates that are thinner, shorter and less structured …

… -terminal β-sheet extending from residues 8 to 17 and a C-terminal β-sheet from residues
28 to 37. While our understanding of the structural and pathological differences of amyloid fibril …

… be dedicated to this peptide and its structural intermediates, but comparisons will be made
… will outline the structural specifics of the different classes of intermediates and mature fibrils, …

… structural models of mature amyloid fibrils. Here, we discuss the pervasive presence of
structural polymorphism in amyloid … structural and mechanistic themes covered in the amyloid …

… of Aß42 intermediates was detectable … of structural intermediates is increased in the
presence of some compounds. After 3 days of incubation, polymeric sheets and fibril intermediates …

… Aβ intermediate structures, we aimed to design inhibitors binding to the β-sheet region of
the Aβ intermediate to interrupt the formation of the pleated β-sheet structure found in amyloid …

… Amyloid formation appears to be preceded by … formation of sticky partially structured
intermediates. This partially … rearrange into amyloid fibrils.11, 17 Similarly, formation of amyloid by …