… spectrum of anticancer activities through … -β-carboline derivatives as potent antitumor
agents via inhibition of both topoisomerase-I and KSP. For further optimization to get anticancer …

… novel chemotherapeutic agents. In this regard, we have reviewed the development of β-carboline-based
chemotherapeutic agents … on the molecular hybrids of β-carbolines with various …

… The complex pathophysiological mechanisms behind cancer progression urge the needs
for developing novel multi-target anticancer drugs to simultaneously cover several …

… as antineoplastic agent through HDAC inhibition), is a feature shared by all reported β-carboline-based
inhibitors. First, introducing the hydroxamic acid function at position 3 of the …

… In an effort to develop anticancer agents that may overcome drug resistance, the number
one reason in caner death, we have developed a series of novel hybrids of β-carboline and N-…

… of human disease, particularly as anticancer agents [8-10]. … development of new
chemotherapeutic agents that are more … β-carboline derivatives as multi-target anticancer agents. …

… β-carboline derivatives as potential antitumor agents. β-Carbolines are potent anticancer
agents … Design and synthesis of some β-carboline derivatives as multi-target anticancer agents. …

… For example, safinamide is a multi-target agent for … hand, different multi-target antineoplastic
agents have been … Therefore, those multi-target agents have provided a suitable …

… broad pharmacological spectrum of β-Carboline (βC) ligands … efficacy as multi-mechanistic
anticancer agents. However, to our … additionally exhibit other multi-target directed actions …

… This review article presents the rational approaches behind the design of anticancer
agents containing bioactive indole moiety employing molecular hybridization as a tool for …