… Among them, compound 110 was found to be the most potent antitumor agent with IC 50
values lower than 15 μM against the ten tested cell lines [84]. In order to continue the study of …

… major scientific leads in the synthesis of various anticancer agents [12,13]. Major bioactive
components of various carbolines alkaloids with saturated or unsaturated tricyclic ring system …

… relationship of β-carboline derivatives as antitumor agents, in … It was proved that substituent
in position-9 of the β-carboline ring … a novel antitumor drug that could surpass Adriamycin. …

… The thiazolidinedione hybrid with quinoline produced potent anti-tumor agents and
among … 22a The highly potent derivatives 48a–b encouraged the design of β-carboline-…

… β-carboline has been revealed through targeting cell division cycle at different phases. In
conclusion, β-carboline … the in vitro anticancer effects of β-carboline alkaloids through targeting …

… activities through different mechanisms of action, this article highlights the 1,2,4-triazolyl-β-carboline
derivatives as potent antitumor agents via inhibition of both topoisomerase-I and …

… to antitumor activity and neurotoxicity/acute toxicity. We report here the preparation of novel
β-carboline derivatives, their antitumor … All the tested compounds exhibited potent antitumor …

… In summary, a number of novel β-carboline derivatives described in this paper proved to be
potent antitumor agents. The N 2 -benzylated β-carbolinium bromides 56–60 were found to …

… potent antitumor activities against Lewis lung cancer in mice than their monovalent β-carboline…
Particularly, compound 22 was found to be the most potent antitumor agent with the tumor …

Bis-β-carboline alkaloids are widely distributed in natural products and represent a promising
drug-like scaffold for discovering drugs and bioactive molecules. In this study, we utilized …